Abstract
The tertiary structure of Ascaris suum mitochondrial tRNAUCUSer was examined by nuclear magnetic resonance analysis using its transcript, since tRNAUCUSer, lacking the D arm and possessing a truncated T arm, is the shortest of all the known tRNAs. Most basepairs in the proposed secondary structure of tRNAUCUSer were shown to exist, but the connector region comprising the truncated D loop and the extra loop was flexible. This flexibility, would enable adjustment of the mutual distance between the 3′-terminus and the anticodon consistent with that of usual tRNAs. Thus, tRNASerUCU appears to function in a similar way to that of usual tRNAs in the ribosome.
Original language | English |
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Pages (from-to) | 37-43 |
Number of pages | 7 |
Journal | FEBS Letters |
Volume | 514 |
Issue number | 1 |
DOIs | |
Publication status | Published - Mar 6 2002 |
Externally published | Yes |
Keywords
- Ascaris suum
- Mitochondrion
- Nematode
- Nuclear magnetic resonance
- Stable isotope
- Unusual tRNA
ASJC Scopus subject areas
- Biophysics
- Structural Biology
- Biochemistry
- Molecular Biology
- Genetics
- Cell Biology