The mechanisms of the development of atherosclerosis in prediabetes

Yin Liang, Mengxue Wang, Chen Wang, Yun Liu, Keiji Naruse, Ken Takahashi

Research output: Contribution to journalReview articlepeer-review

1 Citation (Scopus)

Abstract

Lifestyle changes, such as overeating and underexercising, can increase the risk of predi-abetes. Diabetes is one of the leading causes of atherosclerosis, and recently it became clear that the pathophysiology of atherosclerosis progresses even before the onset of diabetic symptoms. In addi-tion to changes in platelets and leukocytes in the hyperglycemic state and damage to vascular endothelial cells, extracellular vesicles and microRNAs were found to be involved in the progression of prediabetes atherosclerosis. This review discusses the cellular and molecular mechanisms of these processes, with an intention to enable a comprehensive understanding of the pathophysiology of prediabetes and atherosclerosis.

Original languageEnglish
Article number4108
JournalInternational journal of molecular sciences
Volume22
Issue number8
DOIs
Publication statusPublished - Apr 2 2021

Keywords

  • Atherosclerosis
  • Endothelial dysfunction
  • Exosome
  • Metabolic syndrome
  • MicroRNA
  • Obesity
  • Prediabetes

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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