Abstract
Multidrug and toxic compound extrusion (MATE) proteins, comprising the most recently designated family of multidrug transporter proteins, are widely distributed in all kingdoms of living organisms, although their function is far from understood. The bacterial MATE-type transporters that have been characterized function as exporters of cationic drugs, such as norfloxacin and ethidium, through H+ or Na+ exchange. Plant MATE-type transporters are involved in the detoxification of secondary metabolites, including alkaloids. Mammalian MATE-type transporters are responsible for the final step in the excretion of metabolic waste and xenobiotic organic cations in the kidney and liver through electroneutral exchange of H+. Thus, we propose that members of the MATE family are organic cation exporters that excrete metabolic or xenobiotic organic cations from the body.
| Original language | English |
|---|---|
| Pages (from-to) | 587-593 |
| Number of pages | 7 |
| Journal | Trends in Pharmacological Sciences |
| Volume | 27 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - Nov 2006 |
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ASJC Scopus subject areas
- Pharmacology
- Toxicology
Cite this
The MATE proteins as fundamental transporters of metabolic and xenobiotic organic cations. / Omote, Hiroshi; Hiasa, Miki; Matsumoto, Takuya; Otsuka, Masato; Moriyama, Yoshinori.
In: Trends in Pharmacological Sciences, Vol. 27, No. 11, 11.2006, p. 587-593.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The MATE proteins as fundamental transporters of metabolic and xenobiotic organic cations
AU - Omote, Hiroshi
AU - Hiasa, Miki
AU - Matsumoto, Takuya
AU - Otsuka, Masato
AU - Moriyama, Yoshinori
PY - 2006/11
Y1 - 2006/11
N2 - Multidrug and toxic compound extrusion (MATE) proteins, comprising the most recently designated family of multidrug transporter proteins, are widely distributed in all kingdoms of living organisms, although their function is far from understood. The bacterial MATE-type transporters that have been characterized function as exporters of cationic drugs, such as norfloxacin and ethidium, through H+ or Na+ exchange. Plant MATE-type transporters are involved in the detoxification of secondary metabolites, including alkaloids. Mammalian MATE-type transporters are responsible for the final step in the excretion of metabolic waste and xenobiotic organic cations in the kidney and liver through electroneutral exchange of H+. Thus, we propose that members of the MATE family are organic cation exporters that excrete metabolic or xenobiotic organic cations from the body.
AB - Multidrug and toxic compound extrusion (MATE) proteins, comprising the most recently designated family of multidrug transporter proteins, are widely distributed in all kingdoms of living organisms, although their function is far from understood. The bacterial MATE-type transporters that have been characterized function as exporters of cationic drugs, such as norfloxacin and ethidium, through H+ or Na+ exchange. Plant MATE-type transporters are involved in the detoxification of secondary metabolites, including alkaloids. Mammalian MATE-type transporters are responsible for the final step in the excretion of metabolic waste and xenobiotic organic cations in the kidney and liver through electroneutral exchange of H+. Thus, we propose that members of the MATE family are organic cation exporters that excrete metabolic or xenobiotic organic cations from the body.
UR - http://www.scopus.com/inward/record.url?scp=33749988040&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33749988040&partnerID=8YFLogxK
U2 - 10.1016/j.tips.2006.09.001
DO - 10.1016/j.tips.2006.09.001
M3 - Article
C2 - 16996621
AN - SCOPUS:33749988040
VL - 27
SP - 587
EP - 593
JO - Trends in Pharmacological Sciences
JF - Trends in Pharmacological Sciences
SN - 0165-6147
IS - 11
ER -