TY - CHAP
T1 - The manzamine alkaloids
AU - Kubota, Takaaki
AU - Kurimoto, Shin ichiro
AU - Kobayashi, Jun'ichi
N1 - Funding Information:
We thank the late Mr. Zengo Nagahama, the great Okinawan fisherman, for his help with sponge collection. We thank Professor Satoshi ?mura and coworkers, ?mura Satoshi Memorial Institute, Kitasato University, for their help with antiprotozoal activity tests.
Publisher Copyright:
© 2020 Elsevier Inc.
PY - 2020
Y1 - 2020
N2 - The manzamine alkaloids are absolutely one of the most fascinating marine natural products. The representative manzamine alkaloids, manzamines A–C, were isolated from a marine sponge Haliclona sp. collected off Cape Manzamo, Okinawa, Japan. The manzamine alkaloids are a unique class of alkaloids possessing a characteristic heterocyclic system, and exhibit a diverse range of bioactivities including cytotoxicity, antimicrobial activity, antimalarial activity, antiviral and antiinflammatory activities, antiinsecticidal activity, and proteasome inhibitory activity. About 100 manzamine alkaloids have been isolated from more than 16 species of marine sponges belonging to 5 families. The unusual ring systems, an intriguing suggested biogenetic pathway, and promising biological activities of manzamine alkaloids have attracted great interest as challenging targets for the total synthesis. This review is the continuation of the previous review published in volume 60 of The Alkaloids and covers isolation, structure elucidation, biosynthesis and biogenesis, chemical synthesis, and biological activity of manzamine alkaloids reported from 2003 to 2018.
AB - The manzamine alkaloids are absolutely one of the most fascinating marine natural products. The representative manzamine alkaloids, manzamines A–C, were isolated from a marine sponge Haliclona sp. collected off Cape Manzamo, Okinawa, Japan. The manzamine alkaloids are a unique class of alkaloids possessing a characteristic heterocyclic system, and exhibit a diverse range of bioactivities including cytotoxicity, antimicrobial activity, antimalarial activity, antiviral and antiinflammatory activities, antiinsecticidal activity, and proteasome inhibitory activity. About 100 manzamine alkaloids have been isolated from more than 16 species of marine sponges belonging to 5 families. The unusual ring systems, an intriguing suggested biogenetic pathway, and promising biological activities of manzamine alkaloids have attracted great interest as challenging targets for the total synthesis. This review is the continuation of the previous review published in volume 60 of The Alkaloids and covers isolation, structure elucidation, biosynthesis and biogenesis, chemical synthesis, and biological activity of manzamine alkaloids reported from 2003 to 2018.
KW - Biological activity
KW - Biosynthesis
KW - Isolation
KW - Manzamine
KW - Marine natural product
KW - Marine sponge
KW - Structure elucidation
KW - Total synthesis
UR - http://www.scopus.com/inward/record.url?scp=85083574776&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85083574776&partnerID=8YFLogxK
U2 - 10.1016/bs.alkal.2020.03.001
DO - 10.1016/bs.alkal.2020.03.001
M3 - Chapter
C2 - 32416951
AN - SCOPUS:85083574776
SN - 9780128209820
T3 - Alkaloids: Chemistry and Biology
SP - 1
EP - 124
BT - The Alkaloids
A2 - Knölker, Hans-Joachim
PB - Academic Press Inc.
ER -
