TY - JOUR
T1 - The lung cancer database project at the National Cancer Center, Japan
T2 - Study design, corresponding rate and profiles of cohort
AU - Nakaya, Naoki
AU - Goto, Koichi
AU - Saito-Nakaya, Kumi
AU - Inagaki, Masatoshi
AU - Otani, Tetsuya
AU - Akechi, Tatsuo
AU - Nagai, Kanji
AU - Hojo, Fumihiko
AU - Uchitomi, Yosuke
AU - Tsugane, Shoichiro
AU - Nishiwaki, Yutaka
N1 - Funding Information:
This study was supported by the Awardees of Research Resident Fellowship from the Foundation for the Promotion of Cancer Research (Japan) for the 3rd Term Comprehensive Control Research for Cancer. We would like to express special thanks to Toyoko Matsumoto and Fumiko Koh for the collecting and filing the data for this project. We also wish to thank Yuko Kojima, Nobue Taguchi and Ryoko Katayama of the Psycho-Oncology Division, Research Center for Innovative Oncology, National Cancer Center Hospital East, Kashiwa, Japan, for their research assistance.
PY - 2006/5
Y1 - 2006/5
N2 - Background: The lung cancer database project was established in 1999 at the National Cancer Center Hospital East, Japan, as an ongoing project to integrate data on various factors in lung cancer patients. The aim of the project was to construct a large-scale cancer registry for lung cancer that would contribute to basic research and clinical research in the future. Methods: Between July 1999 and July 2004, consecutive lung cancer patients were recruited into this project. The baseline survey consisted of self-administered questionnaires concerning various demographic data, health habits and psychological factors. Medical information was obtained from the patients' medical charts. Urine specimens and blood samples were collected, and DNA was extracted from blood lymphocytes. Results: Out of the 2506 patients who were asked to participate in the project, 2036 (81%) patients with newly diagnosed, untreated primary lung cancer were enrolled. The final analytic cohort consisted of 1995 patients. Virtually all of the 1995 patients (corresponding rate, 99%) completed the questionnaires on demographic data and health habits. The corresponding rates for the questionnaires on psychological factors and dietary habits were 99 and 94%, respectively. In a follow-up survey conducted to determine vital status as of December 2004, a total of 1051 patients (53%) had died and 44 patients (2%) were lost to follow-up. Conclusions: This paper overviews the rationale for initiating the lung cancer database project, Japan. This database should prove useful for researchers examining the pathogenesis of lung cancer and may contribute to the formulation of a framework for cancer treatment.
AB - Background: The lung cancer database project was established in 1999 at the National Cancer Center Hospital East, Japan, as an ongoing project to integrate data on various factors in lung cancer patients. The aim of the project was to construct a large-scale cancer registry for lung cancer that would contribute to basic research and clinical research in the future. Methods: Between July 1999 and July 2004, consecutive lung cancer patients were recruited into this project. The baseline survey consisted of self-administered questionnaires concerning various demographic data, health habits and psychological factors. Medical information was obtained from the patients' medical charts. Urine specimens and blood samples were collected, and DNA was extracted from blood lymphocytes. Results: Out of the 2506 patients who were asked to participate in the project, 2036 (81%) patients with newly diagnosed, untreated primary lung cancer were enrolled. The final analytic cohort consisted of 1995 patients. Virtually all of the 1995 patients (corresponding rate, 99%) completed the questionnaires on demographic data and health habits. The corresponding rates for the questionnaires on psychological factors and dietary habits were 99 and 94%, respectively. In a follow-up survey conducted to determine vital status as of December 2004, a total of 1051 patients (53%) had died and 44 patients (2%) were lost to follow-up. Conclusions: This paper overviews the rationale for initiating the lung cancer database project, Japan. This database should prove useful for researchers examining the pathogenesis of lung cancer and may contribute to the formulation of a framework for cancer treatment.
KW - Follow-up survey
KW - Health habits
KW - Large-scale cancer registry
KW - Lung cancer
KW - Psychological factors
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U2 - 10.1093/jjco/hyl015
DO - 10.1093/jjco/hyl015
M3 - Review article
C2 - 16714298
AN - SCOPUS:33745700675
VL - 36
SP - 280
EP - 284
JO - Japanese Journal of Clinical Oncology
JF - Japanese Journal of Clinical Oncology
SN - 0368-2811
IS - 5
ER -