The localization of basic fibroblast growth factor (FGF-2) in rat submandibular glands.

Y. Hiramatsu, H. Kagami, K. Kosaki, T. Shigetomi, M. Ueda, S. Kobayashi, M. Sakanaka

Research output: Contribution to journalArticle

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Abstract

The immunohistochemical localization of basic fibroblast growth factor (FGF-2) in the submandibular glands of the rat was investigated by use of an antiserum to FGF-2. Nerve fiber bundles with FGF-2-immunoreactivity were found in association with interlobular ducts and blood vessels; they dissociated into single immunoreactive nerve fibers perhaps to terminate in proximity to acinar cells, or to form a reticular fiber network within the tunica adventitia of blood vessels. The FGF-2-immunoreactive neurons were located in the submandibular ganglia, but not in the superior cervical ganglia; hence, at least some of these immunoreactive nerve fibers probably come from the submandibular ganglia and are of parasympathetic origin. Most of the epithelial cells of the intercalated and collecting ducts showed notable FGF-2 immunoreactivity. The characteristic distribution of FGF-2 immunoreactivity in both the neuronal and epithelial tissues of the salivary glands suggests a role of this growth factor in complex physiological processes within the salivary glands.

Original languageEnglish
Pages (from-to)143-152
Number of pages10
JournalNagoya Journal of Medical Science
Volume57
Issue number3-4
Publication statusPublished - Dec 1994
Externally publishedYes

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Submandibular Gland
Fibroblast Growth Factor 2
Parasympathetic Ganglia
Nerve Fibers
Salivary Glands
Blood Vessels
Physiological Phenomena
Reticulin
Adventitia
Superior Cervical Ganglion
Acinar Cells
Immune Sera
Intercellular Signaling Peptides and Proteins
Epithelium
Epithelial Cells
Neurons

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Hiramatsu, Y., Kagami, H., Kosaki, K., Shigetomi, T., Ueda, M., Kobayashi, S., & Sakanaka, M. (1994). The localization of basic fibroblast growth factor (FGF-2) in rat submandibular glands. Nagoya Journal of Medical Science, 57(3-4), 143-152.

The localization of basic fibroblast growth factor (FGF-2) in rat submandibular glands. / Hiramatsu, Y.; Kagami, H.; Kosaki, K.; Shigetomi, T.; Ueda, M.; Kobayashi, S.; Sakanaka, M.

In: Nagoya Journal of Medical Science, Vol. 57, No. 3-4, 12.1994, p. 143-152.

Research output: Contribution to journalArticle

Hiramatsu, Y, Kagami, H, Kosaki, K, Shigetomi, T, Ueda, M, Kobayashi, S & Sakanaka, M 1994, 'The localization of basic fibroblast growth factor (FGF-2) in rat submandibular glands.', Nagoya Journal of Medical Science, vol. 57, no. 3-4, pp. 143-152.
Hiramatsu Y, Kagami H, Kosaki K, Shigetomi T, Ueda M, Kobayashi S et al. The localization of basic fibroblast growth factor (FGF-2) in rat submandibular glands. Nagoya Journal of Medical Science. 1994 Dec;57(3-4):143-152.
Hiramatsu, Y. ; Kagami, H. ; Kosaki, K. ; Shigetomi, T. ; Ueda, M. ; Kobayashi, S. ; Sakanaka, M. / The localization of basic fibroblast growth factor (FGF-2) in rat submandibular glands. In: Nagoya Journal of Medical Science. 1994 ; Vol. 57, No. 3-4. pp. 143-152.
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