The linkage of innate and adaptive immune response during granulomatous development

Toshihiro Ito, Judith M. Connett, Steven L. Kunkel, Akihiro Matsukawa

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Granulomas represent a spectrum of inflammatory sequestration responses that may be initiated by a variety of agents, including non-infectious environmental factors and infectious microbial pathogens. Although this reaction is designed to be protective, the associated tissue injury is often responsible for a profound degree of pathology. While many of the mechanisms that sustain the development of the granuloma are enigmatic, it is accepted that the maintenance of this inflammatory process is dependent upon dynamic interactions between an inciting agent, inflammatory mediators, various immune and inflammatory cells, and structural cells of the involved tissue. The best studied of the host-dependent processes during granuloma development is the innate and adaptive immune response. The innate immune response by antigen-presenting cells [APCs; dendritic cells (DCs) and macrophages] is initiated quickly to protect from overwhelming pathogens, but with time, can also activate the adaptive immune response. APCs, essential regulators of the innate immune response, can respond to microbial ligands through Toll-like receptors (TLRs), which function in the recognition of microbial components and play an important role to link the innate and adaptive immune responses. CD4+ T helper (Th) cells are essential regulators of adaptive immune responses and inflammatory diseases. Recently, the Notch system has been shown to be an important bridge between APCs and T cell communication circuits. In the present review, we discuss recent findings that explore the mechanisms in the linkage of innate and adaptive immunity, including granulomatous formation though TLRs and Notch activation.

Original languageEnglish
Article numberArticle 10
JournalFrontiers in Immunology
Volume4
Issue numberJAN
DOIs
Publication statusPublished - 2013

Fingerprint

Adaptive Immunity
Innate Immunity
Granuloma
Toll-Like Receptors
Histocompatibility Antigens Class II
Antigen-Presenting Cells
Helper-Inducer T-Lymphocytes
Cell Communication
Dendritic Cells
Macrophages
Maintenance
Pathology
Ligands
T-Lymphocytes
Wounds and Injuries

Keywords

  • Acquired immunity
  • Dendritic cell
  • Innate immunity
  • Notch signaling
  • T helper cell
  • Toll-like receptor

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

The linkage of innate and adaptive immune response during granulomatous development. / Ito, Toshihiro; Connett, Judith M.; Kunkel, Steven L.; Matsukawa, Akihiro.

In: Frontiers in Immunology, Vol. 4, No. JAN, Article 10, 2013.

Research output: Contribution to journalArticle

Ito, Toshihiro ; Connett, Judith M. ; Kunkel, Steven L. ; Matsukawa, Akihiro. / The linkage of innate and adaptive immune response during granulomatous development. In: Frontiers in Immunology. 2013 ; Vol. 4, No. JAN.
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