The KCNQ1 gene polymorphism as a shared genetic risk for rheumatoid arthritis and chronic periodontitis in japanese adults: A pilot case-control study

Tetsuo Kobayashi, Jun Ichi Kido, Yuichi Ishihara, Kazuhiro Omori, Satoshi Ito, Takato Matsuura, Takashi Bando, Jun Wada, Akira Murasawa, Kiyoshi Nakazono, Akio Mitani, Shogo Takashiba, Toshihiko Nagata, Hiromasa Yoshie

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background: A number of studies have suggested a bidirectional relationship of periodontitis with rheumatoid arthritis (RA) and type 2 diabetes mellitus (T2DM). However, the genetic factors that underlie these relationships have not been elucidated. Methods: We conducted a multicenter case-control study that included 185 patients with RA and chronic periodontitis (CP), 149 patients with T2DM and CP, 251 patients with CP, and 130 systemically and periodontally healthy controls from a cohort of Japanese adults to assess the shared genetic risk factors for RA and CP as well as for T2DM and CP. A total of 17 candidate single nucleotide polymorphisms (SNPs) associated with RA, T2DM, and CP were genotyped. Results: Multiple logistic regression analyses revealed that the KCNQ1 rs2237892 was significantly associated with comorbidity of RA and CP (P = 0.005) after adjustment for age, sex, and smoking status. The carriers of the T allele among patients with RA and CP showed significantly higher disease activity scores including 28 joints using C-reactive protein values than the non-carriers (P = 0.02), although the age, female percentage, and smoking status were comparable. Other SNPs were not associated with comorbidity of RA and CP, T2DM and CP, or susceptibility to CP. Conclusion: The results of the present pilot study suggest for the first time that the KCNQ1 rs2237892 may constitute a shared genetic risk factor for RA and CP, but not for T2DM and CP in Japanese adults.

Original languageEnglish
Pages (from-to)315-324
Number of pages10
JournalJournal of periodontology
Volume89
Issue number3
DOIs
Publication statusPublished - Jan 1 2018

Keywords

  • Arthritis
  • Case-control studies
  • Comorbidity
  • Diabetes mellitus
  • Periodontitis
  • Polymorphism
  • Rheumatoid
  • Single nucleotide

ASJC Scopus subject areas

  • Periodontics

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  • Cite this

    Kobayashi, T., Kido, J. I., Ishihara, Y., Omori, K., Ito, S., Matsuura, T., Bando, T., Wada, J., Murasawa, A., Nakazono, K., Mitani, A., Takashiba, S., Nagata, T., & Yoshie, H. (2018). The KCNQ1 gene polymorphism as a shared genetic risk for rheumatoid arthritis and chronic periodontitis in japanese adults: A pilot case-control study. Journal of periodontology, 89(3), 315-324. https://doi.org/10.1002/JPER.17-0412