TY - JOUR
T1 - The KCNQ1 gene polymorphism as a shared genetic risk for rheumatoid arthritis and chronic periodontitis in japanese adults
T2 - A pilot case-control study
AU - Kobayashi, Tetsuo
AU - Kido, Jun Ichi
AU - Ishihara, Yuichi
AU - Omori, Kazuhiro
AU - Ito, Satoshi
AU - Matsuura, Takato
AU - Bando, Takashi
AU - Wada, Jun
AU - Murasawa, Akira
AU - Nakazono, Kiyoshi
AU - Mitani, Akio
AU - Takashiba, Shogo
AU - Nagata, Toshihiko
AU - Yoshie, Hiromasa
PY - 2018
Y1 - 2018
N2 - Background: A number of studies have suggested a bidirectional relationship of periodontitis with rheumatoid arthritis (RA) and type 2 diabetes mellitus (T2DM). However, the genetic factors that underlie these relationships have not been elucidated. Methods: We conducted a multicenter case-control study that included 185 patients with RA and chronic periodontitis (CP), 149 patients with T2DM and CP, 251 patients with CP, and 130 systemically and periodontally healthy controls from a cohort of Japanese adults to assess the shared genetic risk factors for RA and CP as well as for T2DM and CP. A total of 17 candidate single nucleotide polymorphisms (SNPs) associated with RA, T2DM, and CP were genotyped. Results: Multiple logistic regression analyses revealed that the KCNQ1 rs2237892 was significantly associated with comorbidity of RA and CP (P = 0.005) after adjustment for age, sex, and smoking status. The carriers of the T allele among patients with RA and CP showed significantly higher disease activity scores including 28 joints using C-reactive protein values than the non-carriers (P = 0.02), although the age, female percentage, and smoking status were comparable. Other SNPs were not associated with comorbidity of RA and CP, T2DM and CP, or susceptibility to CP. Conclusion: The results of the present pilot study suggest for the first time that the KCNQ1 rs2237892 may constitute a shared genetic risk factor for RA and CP, but not for T2DM and CP in Japanese adults.
AB - Background: A number of studies have suggested a bidirectional relationship of periodontitis with rheumatoid arthritis (RA) and type 2 diabetes mellitus (T2DM). However, the genetic factors that underlie these relationships have not been elucidated. Methods: We conducted a multicenter case-control study that included 185 patients with RA and chronic periodontitis (CP), 149 patients with T2DM and CP, 251 patients with CP, and 130 systemically and periodontally healthy controls from a cohort of Japanese adults to assess the shared genetic risk factors for RA and CP as well as for T2DM and CP. A total of 17 candidate single nucleotide polymorphisms (SNPs) associated with RA, T2DM, and CP were genotyped. Results: Multiple logistic regression analyses revealed that the KCNQ1 rs2237892 was significantly associated with comorbidity of RA and CP (P = 0.005) after adjustment for age, sex, and smoking status. The carriers of the T allele among patients with RA and CP showed significantly higher disease activity scores including 28 joints using C-reactive protein values than the non-carriers (P = 0.02), although the age, female percentage, and smoking status were comparable. Other SNPs were not associated with comorbidity of RA and CP, T2DM and CP, or susceptibility to CP. Conclusion: The results of the present pilot study suggest for the first time that the KCNQ1 rs2237892 may constitute a shared genetic risk factor for RA and CP, but not for T2DM and CP in Japanese adults.
KW - Arthritis
KW - Case-control studies
KW - Comorbidity
KW - Diabetes mellitus
KW - Periodontitis
KW - Polymorphism
KW - Rheumatoid
KW - Single nucleotide
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U2 - 10.1002/JPER.17-0412
DO - 10.1002/JPER.17-0412
M3 - Article
C2 - 29520783
AN - SCOPUS:85054588460
VL - 89
SP - 315
EP - 324
JO - Journal of Periodontology
JF - Journal of Periodontology
SN - 0022-3492
IS - 3
ER -