TY - JOUR
T1 - The KCNQ1 gene polymorphism as a shared genetic risk for rheumatoid arthritis and chronic periodontitis in japanese adults
T2 - A pilot case-control study
AU - Kobayashi, Tetsuo
AU - Kido, Jun Ichi
AU - Ishihara, Yuichi
AU - Omori, Kazuhiro
AU - Ito, Satoshi
AU - Matsuura, Takato
AU - Bando, Takashi
AU - Wada, Jun
AU - Murasawa, Akira
AU - Nakazono, Kiyoshi
AU - Mitani, Akio
AU - Takashiba, Shogo
AU - Nagata, Toshihiko
AU - Yoshie, Hiromasa
N1 - Funding Information:
The authors thank all individuals who participated in the present study, and are also grateful to M. Nagano (Division of Advanced Technology and Development, the BML Corporation, Saitama, Japan) for technical support in the genotyp-ing. This study was supported by Grant-in Aid for Scientific Research (No. 25253104) from the Japan Society for the Promotion of Science (JSPS), Tokyo, Japan. The authors report no conflicts of interest related to this study.
PY - 2018
Y1 - 2018
N2 - Background: A number of studies have suggested a bidirectional relationship of periodontitis with rheumatoid arthritis (RA) and type 2 diabetes mellitus (T2DM). However, the genetic factors that underlie these relationships have not been elucidated. Methods: We conducted a multicenter case-control study that included 185 patients with RA and chronic periodontitis (CP), 149 patients with T2DM and CP, 251 patients with CP, and 130 systemically and periodontally healthy controls from a cohort of Japanese adults to assess the shared genetic risk factors for RA and CP as well as for T2DM and CP. A total of 17 candidate single nucleotide polymorphisms (SNPs) associated with RA, T2DM, and CP were genotyped. Results: Multiple logistic regression analyses revealed that the KCNQ1 rs2237892 was significantly associated with comorbidity of RA and CP (P = 0.005) after adjustment for age, sex, and smoking status. The carriers of the T allele among patients with RA and CP showed significantly higher disease activity scores including 28 joints using C-reactive protein values than the non-carriers (P = 0.02), although the age, female percentage, and smoking status were comparable. Other SNPs were not associated with comorbidity of RA and CP, T2DM and CP, or susceptibility to CP. Conclusion: The results of the present pilot study suggest for the first time that the KCNQ1 rs2237892 may constitute a shared genetic risk factor for RA and CP, but not for T2DM and CP in Japanese adults.
AB - Background: A number of studies have suggested a bidirectional relationship of periodontitis with rheumatoid arthritis (RA) and type 2 diabetes mellitus (T2DM). However, the genetic factors that underlie these relationships have not been elucidated. Methods: We conducted a multicenter case-control study that included 185 patients with RA and chronic periodontitis (CP), 149 patients with T2DM and CP, 251 patients with CP, and 130 systemically and periodontally healthy controls from a cohort of Japanese adults to assess the shared genetic risk factors for RA and CP as well as for T2DM and CP. A total of 17 candidate single nucleotide polymorphisms (SNPs) associated with RA, T2DM, and CP were genotyped. Results: Multiple logistic regression analyses revealed that the KCNQ1 rs2237892 was significantly associated with comorbidity of RA and CP (P = 0.005) after adjustment for age, sex, and smoking status. The carriers of the T allele among patients with RA and CP showed significantly higher disease activity scores including 28 joints using C-reactive protein values than the non-carriers (P = 0.02), although the age, female percentage, and smoking status were comparable. Other SNPs were not associated with comorbidity of RA and CP, T2DM and CP, or susceptibility to CP. Conclusion: The results of the present pilot study suggest for the first time that the KCNQ1 rs2237892 may constitute a shared genetic risk factor for RA and CP, but not for T2DM and CP in Japanese adults.
KW - Arthritis
KW - Case-control studies
KW - Comorbidity
KW - Diabetes mellitus
KW - Periodontitis
KW - Polymorphism
KW - Rheumatoid
KW - Single nucleotide
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U2 - 10.1002/JPER.17-0412
DO - 10.1002/JPER.17-0412
M3 - Article
C2 - 29520783
AN - SCOPUS:85054588460
SN - 0022-3492
VL - 89
SP - 315
EP - 324
JO - Journal of Periodontology
JF - Journal of Periodontology
IS - 3
ER -