The junctional epithelium originates from the odontogenic epithelium of an erupted tooth

Sara Yajima-Himuro, Masamitsu Oshima, Gou Yamamoto, Miho Ogawa, Madoka Furuya, Junichi Tanaka, Kousuke Nishii, Kenji Mishima, Tetsuhiko Tachikawa, Takashi Tsuji, Matsuo Yamamoto

Research output: Contribution to journalArticle

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Abstract

The junctional epithelium (JE) is an epithelial component that is directly attached to the tooth surface and has a protective function against periodontal diseases. In this study, we determined the origin of the JE using a bioengineered tooth technique. We transplanted the bioengineered tooth germ into the alveolar bone with an epithelial component that expressed green fluorescence protein. The reduced enamel epithelium from the bioengineered tooth fused with the oral epithelium, and the JE was apparently formed around the bioengineered tooth 50 days after transplantation. Importantly, the JE exhibited green fluorescence for at least 140 days after transplantation, suggesting that the JE was not replaced by oral epithelium. Therefore, our results demonstrated that the origin of the JE was the odontogenic epithelium, and odontogenic epithelium-derived JE was maintained for a relatively long period.

Original languageEnglish
Article number4867
JournalScientific Reports
Volume4
DOIs
Publication statusPublished - May 2 2014
Externally publishedYes

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Epithelial Attachment
Tooth
Epithelium
Fused Teeth
Transplantation
Fluorescence
Tooth Germ
Periodontal Diseases
Dental Enamel
Bone and Bones

ASJC Scopus subject areas

  • General

Cite this

Yajima-Himuro, S., Oshima, M., Yamamoto, G., Ogawa, M., Furuya, M., Tanaka, J., ... Yamamoto, M. (2014). The junctional epithelium originates from the odontogenic epithelium of an erupted tooth. Scientific Reports, 4, [4867]. https://doi.org/10.1038/srep04867

The junctional epithelium originates from the odontogenic epithelium of an erupted tooth. / Yajima-Himuro, Sara; Oshima, Masamitsu; Yamamoto, Gou; Ogawa, Miho; Furuya, Madoka; Tanaka, Junichi; Nishii, Kousuke; Mishima, Kenji; Tachikawa, Tetsuhiko; Tsuji, Takashi; Yamamoto, Matsuo.

In: Scientific Reports, Vol. 4, 4867, 02.05.2014.

Research output: Contribution to journalArticle

Yajima-Himuro, S, Oshima, M, Yamamoto, G, Ogawa, M, Furuya, M, Tanaka, J, Nishii, K, Mishima, K, Tachikawa, T, Tsuji, T & Yamamoto, M 2014, 'The junctional epithelium originates from the odontogenic epithelium of an erupted tooth', Scientific Reports, vol. 4, 4867. https://doi.org/10.1038/srep04867
Yajima-Himuro S, Oshima M, Yamamoto G, Ogawa M, Furuya M, Tanaka J et al. The junctional epithelium originates from the odontogenic epithelium of an erupted tooth. Scientific Reports. 2014 May 2;4. 4867. https://doi.org/10.1038/srep04867
Yajima-Himuro, Sara ; Oshima, Masamitsu ; Yamamoto, Gou ; Ogawa, Miho ; Furuya, Madoka ; Tanaka, Junichi ; Nishii, Kousuke ; Mishima, Kenji ; Tachikawa, Tetsuhiko ; Tsuji, Takashi ; Yamamoto, Matsuo. / The junctional epithelium originates from the odontogenic epithelium of an erupted tooth. In: Scientific Reports. 2014 ; Vol. 4.
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