The Japanese toxicogenomics project: Application of toxicogenomics

Takeki Uehara; Atsushi Ono; Toshiyuki Maruyama; Ikuo Kato; Hiroshi Yamada; Yasuo Ohno; Tetsuro Urushidani

doi:10.1002/mnfr.200900169

The Japanese toxicogenomics project: Application of toxicogenomics

Takeki Uehara, Atsushi Ono, Toshiyuki Maruyama, Ikuo Kato, Hiroshi Yamada, Yasuo Ohno, Tetsuro Urushidani

Research output: Contribution to journal › Review article › peer-review

153 Citations (Scopus)

Abstract

Biotechnology advances have provided novel methods for the risk assessment of chemicals. The application of microarray technologies to toxicology, known as toxicogenomics, is becoming an accepted approach for identifying chemicals with potential safety problems. Gene expression profiling is expected to identify the mechanisms that underlie the potential toxicity of chemicals. This technology has also been applied to identify biomarkers of toxicity to predict potential hazardous chemicals. Ultimately, toxicogenomics is expected to aid in risk assessment. The following discussion explores potential applications and features of the Japanese Toxicogenomics Project.

Original language	English
Pages (from-to)	218-227
Number of pages	10
Journal	Molecular Nutrition and Food Research
Volume	54
Issue number	2
DOIs	https://doi.org/10.1002/mnfr.200900169
Publication status	Published - Feb 2010
Externally published	Yes

Keywords

Genomic biomarker
Hepatotoxicity
Microarray
Toxicogenomics
Toxicogenomics project

ASJC Scopus subject areas

Biotechnology
Food Science

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/mnfr.200900169

Cite this

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AU - Kato, Ikuo

AU - Yamada, Hiroshi

AU - Ohno, Yasuo

AU - Urushidani, Tetsuro

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AB - Biotechnology advances have provided novel methods for the risk assessment of chemicals. The application of microarray technologies to toxicology, known as toxicogenomics, is becoming an accepted approach for identifying chemicals with potential safety problems. Gene expression profiling is expected to identify the mechanisms that underlie the potential toxicity of chemicals. This technology has also been applied to identify biomarkers of toxicity to predict potential hazardous chemicals. Ultimately, toxicogenomics is expected to aid in risk assessment. The following discussion explores potential applications and features of the Japanese Toxicogenomics Project.

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The Japanese toxicogenomics project: Application of toxicogenomics

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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