The Japanese toxicogenomics project: Application of toxicogenomics

Takeki Uehara, Atsushi Ono, Toshiyuki Maruyama, Ikuo Kato, Hiroshi Yamada, Yasuo Ohno, Tetsuro Urushidani

Research output: Contribution to journalReview article

135 Citations (Scopus)

Abstract

Biotechnology advances have provided novel methods for the risk assessment of chemicals. The application of microarray technologies to toxicology, known as toxicogenomics, is becoming an accepted approach for identifying chemicals with potential safety problems. Gene expression profiling is expected to identify the mechanisms that underlie the potential toxicity of chemicals. This technology has also been applied to identify biomarkers of toxicity to predict potential hazardous chemicals. Ultimately, toxicogenomics is expected to aid in risk assessment. The following discussion explores potential applications and features of the Japanese Toxicogenomics Project.

Original languageEnglish
Pages (from-to)218-227
Number of pages10
JournalMolecular Nutrition and Food Research
Volume54
Issue number2
DOIs
Publication statusPublished - Feb 1 2010
Externally publishedYes

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Keywords

  • Genomic biomarker
  • Hepatotoxicity
  • Microarray
  • Toxicogenomics
  • Toxicogenomics project

ASJC Scopus subject areas

  • Biotechnology
  • Food Science

Cite this

Uehara, T., Ono, A., Maruyama, T., Kato, I., Yamada, H., Ohno, Y., & Urushidani, T. (2010). The Japanese toxicogenomics project: Application of toxicogenomics. Molecular Nutrition and Food Research, 54(2), 218-227. https://doi.org/10.1002/mnfr.200900169