The inhibitory effect and possible mechanisms of D-allose on cancer cell proliferation

Li Sui, Youyi Dong, Yasuo Watanabe, Fuminori Yamaguchi, Naoya Hatano, Ikuko Tsukamoto, Ken Izumori, Masaaki Tokuda

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66 Citations (Scopus)

Abstract

Rare sugars are monosaccharides distributed rarely in nature, because of its very limited amount and cost, the biological effect has hardly been studied. Recently, an effective strategy for mass production of rare sugars has been developed. As a result, a wide range of study of rare sugars from the basic to applied research has become possible. For biological application of rare sugars, it is necessary to fundamentally investigate the relationships between rare sugars and living cells in terms of physiology. Therefore, we firstly examined the effect of rare sugars including Dpsicose, D-allose, D-altrose and D-talitoI on cell proliferation using certain cell lines in vitro. Cell growth was evaluated by MTT assay after 24-, 48- and 72-h treatment. The result shows that D-allose has a significant inhibitory effect on cancer cell proliferation in a dose-dependent manner. Although the exact mechanism remains unclear, this finding represents a novel aspect of the biological profile of D-allose and suggests that D-allose may be an effective adjuvant therapeutic agent against cancer in the future.

Original languageEnglish
Pages (from-to)907-912
Number of pages6
JournalInternational journal of oncology
Volume27
Issue number4
Publication statusPublished - Oct 1 2005
Externally publishedYes

Keywords

  • Cancer cell proliferation
  • D-allose
  • Rare sugars

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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  • Cite this

    Sui, L., Dong, Y., Watanabe, Y., Yamaguchi, F., Hatano, N., Tsukamoto, I., Izumori, K., & Tokuda, M. (2005). The inhibitory effect and possible mechanisms of D-allose on cancer cell proliferation. International journal of oncology, 27(4), 907-912.