Abstract
The effects of the antidepressant drugs zimeldine, imipramine, maprotiline or nomifensine on mitochondrial monoamine oxidase (MAO) activity in mouse, rat, dog and monkey brains were compared in vitro. Mouse, rat, dog and monkey brain MAO-B activities were inhibited by zimeldine more potently than MAO-A activity. Imipramine inhibited MAO-B more potently than MAO-A activity in mouse and rat brains. When dog and monkey brains were investigated, MAO-A activity was inhibited more potently than MAO-B activity at high concentrations of imipramine, while at low concentrations, MAO-B activity was more potently inhibited. Maprotiline and nomifensine inhibited mouse and rat brain MAO-B activity more potently than MAO-A activity, while the inverse was true for dog and monkey brains. All four drugs are competitive inhibitors of MAO-A, but noncompetitive inhibitors of MAO-B in all animal brains. The respective K(i) values of these reagents for monkey brain MAO-A and MAO-B were low compared to those of mouse, rat and dog. These results indicate that monkey brain MAOs are more sensitive to antidepressant drugs than those in rodent brain.
| Original language | English |
|---|---|
| Pages (from-to) | 115-121 |
| Number of pages | 7 |
| Journal | Japanese Journal of Pharmacology |
| Volume | 81 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 1999 |
| Externally published | Yes |
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Keywords
- Animal species
- Antidepressant
- Brain
- Monoamine oxidase A
- Monoamine oxidase B
ASJC Scopus subject areas
- Pharmacology
- Molecular Medicine
Cite this
The inhibition of monoamine oxidase activity by various antidepressants : Differences found in various mammalian species. / Egashira, Toru; Takayama, Fusako; Yamanaka, Yasumitsu.
In: Japanese Journal of Pharmacology, Vol. 81, No. 1, 1999, p. 115-121.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The inhibition of monoamine oxidase activity by various antidepressants
T2 - Differences found in various mammalian species
AU - Egashira, Toru
AU - Takayama, Fusako
AU - Yamanaka, Yasumitsu
PY - 1999
Y1 - 1999
N2 - The effects of the antidepressant drugs zimeldine, imipramine, maprotiline or nomifensine on mitochondrial monoamine oxidase (MAO) activity in mouse, rat, dog and monkey brains were compared in vitro. Mouse, rat, dog and monkey brain MAO-B activities were inhibited by zimeldine more potently than MAO-A activity. Imipramine inhibited MAO-B more potently than MAO-A activity in mouse and rat brains. When dog and monkey brains were investigated, MAO-A activity was inhibited more potently than MAO-B activity at high concentrations of imipramine, while at low concentrations, MAO-B activity was more potently inhibited. Maprotiline and nomifensine inhibited mouse and rat brain MAO-B activity more potently than MAO-A activity, while the inverse was true for dog and monkey brains. All four drugs are competitive inhibitors of MAO-A, but noncompetitive inhibitors of MAO-B in all animal brains. The respective K(i) values of these reagents for monkey brain MAO-A and MAO-B were low compared to those of mouse, rat and dog. These results indicate that monkey brain MAOs are more sensitive to antidepressant drugs than those in rodent brain.
AB - The effects of the antidepressant drugs zimeldine, imipramine, maprotiline or nomifensine on mitochondrial monoamine oxidase (MAO) activity in mouse, rat, dog and monkey brains were compared in vitro. Mouse, rat, dog and monkey brain MAO-B activities were inhibited by zimeldine more potently than MAO-A activity. Imipramine inhibited MAO-B more potently than MAO-A activity in mouse and rat brains. When dog and monkey brains were investigated, MAO-A activity was inhibited more potently than MAO-B activity at high concentrations of imipramine, while at low concentrations, MAO-B activity was more potently inhibited. Maprotiline and nomifensine inhibited mouse and rat brain MAO-B activity more potently than MAO-A activity, while the inverse was true for dog and monkey brains. All four drugs are competitive inhibitors of MAO-A, but noncompetitive inhibitors of MAO-B in all animal brains. The respective K(i) values of these reagents for monkey brain MAO-A and MAO-B were low compared to those of mouse, rat and dog. These results indicate that monkey brain MAOs are more sensitive to antidepressant drugs than those in rodent brain.
KW - Animal species
KW - Antidepressant
KW - Brain
KW - Monoamine oxidase A
KW - Monoamine oxidase B
UR - http://www.scopus.com/inward/record.url?scp=0032851058&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032851058&partnerID=8YFLogxK
U2 - 10.1254/jjp.81.115
DO - 10.1254/jjp.81.115
M3 - Article
C2 - 10580379
AN - SCOPUS:0032851058
VL - 81
SP - 115
EP - 121
JO - Japanese Journal of Pharmacology
JF - Japanese Journal of Pharmacology
SN - 0021-5198
IS - 1
ER -