The influence of hyperactivity of the hypothalamic-pituitary-adrenal axis and hyperglycemia on the 5-HT2A receptor-mediated wet-dog shake responses in rats

Yuichi Umeda, Manabu Amano, Katsuya Suemaru, Takumi Yamaguchi, Yoshihisa Kitamura, Yutaka Gomita, Hiromu Kawasaki, Hiroaki Araki

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Hyperactivity of the hypothalamic-pituitary-adrenal (HPA) axis induces hyperglycemia and serotonin (5-HT)2A receptor supersensitivity. In the present study, to investigate the effect of hyperglycemia on the function of 5-HT2A receptors, we compared the 5-HT2A receptor-mediated wet-dog shake responses in rats treated with adrenocorticotropic hormone (ACTH), dexamethasone and streptozotocin. ACTH (100 μg/rat per day, s.c.), dexamethasone (1 mg/kg per day, s.c.) and streptozotocin (60 mg/kg, i.p.) produced significant hyperglycemia at 14 days after the start of these treatments, and the hyperglycemia was most pronounced in the streptozotocin-treated rats. The wet-dog shake responses induced by (±)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI), a 5-HT 2A receptor agonist, were significantly enhanced at 14 days after repeated treatment with ACTH and dexamethasone. However, streptozotocin-induced diabetes had no effect on the wet-dog shake responses. The results of the present study suggest that hyperglycemia is not strongly associated with the enhanced susceptibility of 5-HT2A receptors under the condition of hyperactivity of the HPA axis. Copyright

Original languageEnglish
Pages (from-to)311-317
Number of pages7
JournalActa medica Okayama
Volume61
Issue number6
Publication statusPublished - Dec 2007

Keywords

  • 5-HT receptor
  • ACTH
  • Dexamethasone
  • Hyperglycemia
  • Streptozotocin

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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    Umeda, Y., Amano, M., Suemaru, K., Yamaguchi, T., Kitamura, Y., Gomita, Y., Kawasaki, H., & Araki, H. (2007). The influence of hyperactivity of the hypothalamic-pituitary-adrenal axis and hyperglycemia on the 5-HT2A receptor-mediated wet-dog shake responses in rats. Acta medica Okayama, 61(6), 311-317.