Abstract
Implantation of a single anterior pituitary into the uterine lumen induced the high incidence of adenomyosis in SHN strain of mice. The subserous nodules of the advanced state of adenomyosis appeared in larger numbers in the right uterine horns bearing the pituitary isografts than in the left ones bearing no isografts. Ovariectomy after implantation completely eliminated the occurrence of adenomyosis. Meanwhile, continuous treatments with estrogen in combination with progesterone recovered such pathological state in the ovariectomized mice receiving the pituitary isografts. The circulating levels of prolactin were consistently higher in mice given pituitary isografts than in the controls given isografts of pieces of submaxillary glands. The results indicate that, in this system, prolactin plays an important role in the genesis of adenomyosis, although the effect of ovarian sex steroids cannot be excluded.
| Original language | English |
|---|---|
| Pages (from-to) | 1277-1282 |
| Number of pages | 6 |
| Journal | Life Sciences |
| Volume | 29 |
| Issue number | 12 |
| DOIs | |
| Publication status | Published - Sep 21 1981 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Pharmacology, Toxicology and Pharmaceutics(all)
Cite this
The induction of adenomyosis in mice by intrauterine pituitary isografts. / Mori, Takao; Nagasawa, Hiroshi; Takahashi, Sumio.
In: Life Sciences, Vol. 29, No. 12, 21.09.1981, p. 1277-1282.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The induction of adenomyosis in mice by intrauterine pituitary isografts
AU - Mori, Takao
AU - Nagasawa, Hiroshi
AU - Takahashi, Sumio
PY - 1981/9/21
Y1 - 1981/9/21
N2 - Implantation of a single anterior pituitary into the uterine lumen induced the high incidence of adenomyosis in SHN strain of mice. The subserous nodules of the advanced state of adenomyosis appeared in larger numbers in the right uterine horns bearing the pituitary isografts than in the left ones bearing no isografts. Ovariectomy after implantation completely eliminated the occurrence of adenomyosis. Meanwhile, continuous treatments with estrogen in combination with progesterone recovered such pathological state in the ovariectomized mice receiving the pituitary isografts. The circulating levels of prolactin were consistently higher in mice given pituitary isografts than in the controls given isografts of pieces of submaxillary glands. The results indicate that, in this system, prolactin plays an important role in the genesis of adenomyosis, although the effect of ovarian sex steroids cannot be excluded.
AB - Implantation of a single anterior pituitary into the uterine lumen induced the high incidence of adenomyosis in SHN strain of mice. The subserous nodules of the advanced state of adenomyosis appeared in larger numbers in the right uterine horns bearing the pituitary isografts than in the left ones bearing no isografts. Ovariectomy after implantation completely eliminated the occurrence of adenomyosis. Meanwhile, continuous treatments with estrogen in combination with progesterone recovered such pathological state in the ovariectomized mice receiving the pituitary isografts. The circulating levels of prolactin were consistently higher in mice given pituitary isografts than in the controls given isografts of pieces of submaxillary glands. The results indicate that, in this system, prolactin plays an important role in the genesis of adenomyosis, although the effect of ovarian sex steroids cannot be excluded.
UR - http://www.scopus.com/inward/record.url?scp=0019777979&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0019777979&partnerID=8YFLogxK
U2 - 10.1016/0024-3205(81)90234-4
DO - 10.1016/0024-3205(81)90234-4
M3 - Article
C2 - 7300555
AN - SCOPUS:0019777979
VL - 29
SP - 1277
EP - 1282
JO - Life Sciences
JF - Life Sciences
SN - 0024-3205
IS - 12
ER -