The induction of adenomyosis in mice by intrauterine pituitary isografts

Takao Mori, Hiroshi Nagasawa, Sumio Takahashi

Research output: Contribution to journalArticlepeer-review

60 Citations (Scopus)


Implantation of a single anterior pituitary into the uterine lumen induced the high incidence of adenomyosis in SHN strain of mice. The subserous nodules of the advanced state of adenomyosis appeared in larger numbers in the right uterine horns bearing the pituitary isografts than in the left ones bearing no isografts. Ovariectomy after implantation completely eliminated the occurrence of adenomyosis. Meanwhile, continuous treatments with estrogen in combination with progesterone recovered such pathological state in the ovariectomized mice receiving the pituitary isografts. The circulating levels of prolactin were consistently higher in mice given pituitary isografts than in the controls given isografts of pieces of submaxillary glands. The results indicate that, in this system, prolactin plays an important role in the genesis of adenomyosis, although the effect of ovarian sex steroids cannot be excluded.

Original languageEnglish
Pages (from-to)1277-1282
Number of pages6
JournalLife Sciences
Issue number12
Publication statusPublished - Sep 21 1981
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)


Dive into the research topics of 'The induction of adenomyosis in mice by intrauterine pituitary isografts'. Together they form a unique fingerprint.

Cite this