The inclusion of blastomeres into the inner cell mass in early-stage human embryos depends on the sequence of cell cleavages during the fourth division

Junko Otsuki, Toshiroh Iwasaki, Noritoshi Enatsu, Yuya Katada, Kohyu Furuhashi, Masahide Shiotani

Research output: Contribution to journalArticlepeer-review

Abstract

The fate of the ICM in humans is still unknown, due to the ethical difficulties surrounding experimentation in this field. In this study we have explored the existing time-lapse recording data of embryos in the early stages of development, taking advantage of the large refractile bodies (RBs) within blastomeres as cellular markers. Our study found that the cellular composition of the ICM in humans is largely determined at the time of the fourth division and blastomeres which cleave first to fourth, during the fourth division from 8 cells to 16 cells, have the potential to be incorporated in the ICM.

Original languageEnglish
Article numbere0240936
JournalPloS one
Volume15
Issue number10 October
DOIs
Publication statusPublished - Oct 2020

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

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