The incidence and prognostic value of hypochloremia in critically ill patients

Makiko Tani, Hiroshi Morimatsu, Fumiaki Takatsu, Kiyoshi Morita

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Little is known on the clinical effects of chloride on critically ill patients. We conducted this retrospective, observational study in 488 critically ill patients to investigate the incidence of chloride abnormalities, effects of hypochloremia in acid-base disorders, and association between chloride and clinical outcome. The study involved retrieval of arterial blood gas analyses, biochemical and demographical data from electrical records as well as quantitative acid-base analyses. For statistical analysis, the patients were stratified into three groups according to their chloride level (normal range: 98-106 mEq/L). The distribution of chloride levels was hyperchloremia 16.6%, normochloremia 74.6%, and hypochloremia 8.8%. The hypochloremic group was significantly alkalemic (P <0.0001) and has significantly higher apparent strong ion difference (SIDa) (P <0.0001) compared to the two other groups. The hypochloremic group had significantly longer stays in the ICU and hospital (P <0.0001) with higher mortality (P <0.0001). However, multiple regression analysis showed that chloride was not an independent factor of poorer outcome. In conclusion, the acid-base characteristics of the hypochloremic patients were alkalemia coexisting with higher SIDa. And although it was not an independent prognostic factor, hypochloremia was related to poorer outcome in critically ill settings.

Original languageEnglish
Article number474185
JournalThe Scientific World Journal
Volume2012
DOIs
Publication statusPublished - 2012

Fingerprint

Critical Illness
Chlorides
chloride
Incidence
Acids
acid
Intensive care units
Blood Gas Analysis
abnormality
Regression analysis
multiple regression
Observational Studies
Statistical methods
regression analysis
Reference Values
statistical analysis
Blood
Retrospective Studies
Gases
blood

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Environmental Science(all)
  • Medicine(all)

Cite this

The incidence and prognostic value of hypochloremia in critically ill patients. / Tani, Makiko; Morimatsu, Hiroshi; Takatsu, Fumiaki; Morita, Kiyoshi.

In: The Scientific World Journal, Vol. 2012, 474185, 2012.

Research output: Contribution to journalArticle

@article{edd853802c5d4f76a99173dcd90dd626,
title = "The incidence and prognostic value of hypochloremia in critically ill patients",
abstract = "Little is known on the clinical effects of chloride on critically ill patients. We conducted this retrospective, observational study in 488 critically ill patients to investigate the incidence of chloride abnormalities, effects of hypochloremia in acid-base disorders, and association between chloride and clinical outcome. The study involved retrieval of arterial blood gas analyses, biochemical and demographical data from electrical records as well as quantitative acid-base analyses. For statistical analysis, the patients were stratified into three groups according to their chloride level (normal range: 98-106 mEq/L). The distribution of chloride levels was hyperchloremia 16.6{\%}, normochloremia 74.6{\%}, and hypochloremia 8.8{\%}. The hypochloremic group was significantly alkalemic (P <0.0001) and has significantly higher apparent strong ion difference (SIDa) (P <0.0001) compared to the two other groups. The hypochloremic group had significantly longer stays in the ICU and hospital (P <0.0001) with higher mortality (P <0.0001). However, multiple regression analysis showed that chloride was not an independent factor of poorer outcome. In conclusion, the acid-base characteristics of the hypochloremic patients were alkalemia coexisting with higher SIDa. And although it was not an independent prognostic factor, hypochloremia was related to poorer outcome in critically ill settings.",
author = "Makiko Tani and Hiroshi Morimatsu and Fumiaki Takatsu and Kiyoshi Morita",
year = "2012",
doi = "10.1100/2012/474185",
language = "English",
volume = "2012",
journal = "The Scientific World Journal",
issn = "1537-744X",
publisher = "Hindawi Publishing Corporation",

}

TY - JOUR

T1 - The incidence and prognostic value of hypochloremia in critically ill patients

AU - Tani, Makiko

AU - Morimatsu, Hiroshi

AU - Takatsu, Fumiaki

AU - Morita, Kiyoshi

PY - 2012

Y1 - 2012

N2 - Little is known on the clinical effects of chloride on critically ill patients. We conducted this retrospective, observational study in 488 critically ill patients to investigate the incidence of chloride abnormalities, effects of hypochloremia in acid-base disorders, and association between chloride and clinical outcome. The study involved retrieval of arterial blood gas analyses, biochemical and demographical data from electrical records as well as quantitative acid-base analyses. For statistical analysis, the patients were stratified into three groups according to their chloride level (normal range: 98-106 mEq/L). The distribution of chloride levels was hyperchloremia 16.6%, normochloremia 74.6%, and hypochloremia 8.8%. The hypochloremic group was significantly alkalemic (P <0.0001) and has significantly higher apparent strong ion difference (SIDa) (P <0.0001) compared to the two other groups. The hypochloremic group had significantly longer stays in the ICU and hospital (P <0.0001) with higher mortality (P <0.0001). However, multiple regression analysis showed that chloride was not an independent factor of poorer outcome. In conclusion, the acid-base characteristics of the hypochloremic patients were alkalemia coexisting with higher SIDa. And although it was not an independent prognostic factor, hypochloremia was related to poorer outcome in critically ill settings.

AB - Little is known on the clinical effects of chloride on critically ill patients. We conducted this retrospective, observational study in 488 critically ill patients to investigate the incidence of chloride abnormalities, effects of hypochloremia in acid-base disorders, and association between chloride and clinical outcome. The study involved retrieval of arterial blood gas analyses, biochemical and demographical data from electrical records as well as quantitative acid-base analyses. For statistical analysis, the patients were stratified into three groups according to their chloride level (normal range: 98-106 mEq/L). The distribution of chloride levels was hyperchloremia 16.6%, normochloremia 74.6%, and hypochloremia 8.8%. The hypochloremic group was significantly alkalemic (P <0.0001) and has significantly higher apparent strong ion difference (SIDa) (P <0.0001) compared to the two other groups. The hypochloremic group had significantly longer stays in the ICU and hospital (P <0.0001) with higher mortality (P <0.0001). However, multiple regression analysis showed that chloride was not an independent factor of poorer outcome. In conclusion, the acid-base characteristics of the hypochloremic patients were alkalemia coexisting with higher SIDa. And although it was not an independent prognostic factor, hypochloremia was related to poorer outcome in critically ill settings.

UR - http://www.scopus.com/inward/record.url?scp=84863757584&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84863757584&partnerID=8YFLogxK

U2 - 10.1100/2012/474185

DO - 10.1100/2012/474185

M3 - Article

C2 - 22701359

AN - SCOPUS:84863757584

VL - 2012

JO - The Scientific World Journal

JF - The Scientific World Journal

SN - 1537-744X

M1 - 474185

ER -