The incidence and pathology of conjunctival ulceration in Behçet's syndrome

Toshihiko Matsuo, Masako Itami, Hideki Nakagawa, Mikio Nagayama

Research output: Contribution to journalArticle

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Abstract

Aims: To describe the results of a study of the incidence of conjunctival ulceration and its pathology as a manifestation of Behçet's syndrome. Methods: The authors reviewed retrospectively medical charts of 152 patients with Behçet's syndrome seen at the uveitis service of Okayama University Hospital from January 1995 to December 1999. Criteria used to diagnose Behçet's syndrome in this study required the presence of oral aphthous ulceration plus any two of three other manifestations - genital ulceration, eye lesions such as iridocyclitis and uveoretinitis, or skin lesions such as erythema nodosum. The presence of conjunctival ulceration was determined in patients with Behçet's syndrome through standardised ophthalmological examinations. A biopsy of the conjunctival ulceration was performed in one patient. The incidence of conjunctival ulceration in patients with Behçet's syndrome was calculated and the clinical and pathological features of this ulceration were examined. Results: Four of 152 patients (2.6%) developed conjunctival ulceration in concordance with exacerbation of their systemic symptoms. Histopathological examinations of a conjunctival biopsy specimen in one patient revealed intraepithelial and perivascular infiltration with neutrophils and lymphocytes, consistent with Behçet's syndrome. The conjunctival ulcerations of the study patients showed good response to topical corticosteroids or topical steroids plus oral colchicine. Conclusions: Conjunctival ulceration should be noted as an uncommon but possible manifestation of Behçet's syndrome. Accordingly, routine examination of the conjunctiva is recommended in patients with Behçet's syndrome, and Behçet's syndrome should be included in a list of differential diagnoses for patients with conjunctival ulcerations.

Original languageEnglish
Pages (from-to)140-143
Number of pages4
JournalBritish Journal of Ophthalmology
Volume86
Issue number2
DOIs
Publication statusPublished - 2002

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Pathology
Incidence
Iridocyclitis
Biopsy
Erythema Nodosum
Neutrophil Infiltration
Conjunctiva
Uveitis
Colchicine
Adrenal Cortex Hormones
Differential Diagnosis
Cohort Studies
Steroids
Lymphocytes
Skin

ASJC Scopus subject areas

  • Ophthalmology

Cite this

The incidence and pathology of conjunctival ulceration in Behçet's syndrome. / Matsuo, Toshihiko; Itami, Masako; Nakagawa, Hideki; Nagayama, Mikio.

In: British Journal of Ophthalmology, Vol. 86, No. 2, 2002, p. 140-143.

Research output: Contribution to journalArticle

Matsuo, Toshihiko ; Itami, Masako ; Nakagawa, Hideki ; Nagayama, Mikio. / The incidence and pathology of conjunctival ulceration in Behçet's syndrome. In: British Journal of Ophthalmology. 2002 ; Vol. 86, No. 2. pp. 140-143.
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