The important pitfalls in the diagnosis of cancer in the oral cavity using 18F-FDG-PET-CT

Shinji Kito, Hirofumi Koga, Masafumi Oda, Tatsurou Tanaka, Masaaki Kodama, Manabu Habu, Ikuya Miyamoto, Shinya Kokuryo, Noriaki Yamamoto, Shinobu Matsumoto-Takeda, Daigo Yoshiga, Takanobu Nishino, Shun Nishimura, Naomi Yada, Noriaki Kawanabe, Kou Matsuo, Masataka Uehara, Masaaki Sasaguri, Tetsuro Konoo, Izumi YoshiokaKazuhiro Tominaga, Yasuhiro Morimoto

Research output: Contribution to journalArticle

Abstract

Recently, a considerable amount of research has focused on the use of positron emission tomography (PET) using fluorine-18-labeled (18F) fluoro-2-deoxy-D-glucose (FDG) as an important oncologic imaging tool in the oral and maxillofacial region. PET using 18F-FDG is especially useful to differentiate benign or malignant primary tumors in oral cancer. However, the normal anatomy of the oral and maxillofacial region is very complex, and substantial variations in uptake are observed in and around the oral cavity. Therefore, there were some cases of oral cancer which were difficult for radiologists to diagnose precisely. In this review, we discuss why normal tissues, dental-related metal artifacts, and dental infections are considered to be the important pitfalls in the diagnosis of primary oral cancers using 18F-FDG-PET-CT.

Original languageEnglish
Pages (from-to)503-514
Number of pages12
JournalInternational Journal of Cancer Research and Prevention
Volume8
Issue number4
Publication statusPublished - 2015

Keywords

  • F-FDG
  • Oral cancers
  • Oral cavity
  • PET-CT
  • Pitfalls

ASJC Scopus subject areas

  • Social Psychology
  • Oncology

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  • Cite this

    Kito, S., Koga, H., Oda, M., Tanaka, T., Kodama, M., Habu, M., Miyamoto, I., Kokuryo, S., Yamamoto, N., Matsumoto-Takeda, S., Yoshiga, D., Nishino, T., Nishimura, S., Yada, N., Kawanabe, N., Matsuo, K., Uehara, M., Sasaguri, M., Konoo, T., ... Morimoto, Y. (2015). The important pitfalls in the diagnosis of cancer in the oral cavity using 18F-FDG-PET-CT. International Journal of Cancer Research and Prevention, 8(4), 503-514.