The impact of triple drug immunosuppression on clinical results of cadaveric kidney transplantation: a comparison of conventional immunosuppression.

K. Sakagami, S. Saito, S. Shiozaki, S. Takasu, T. Matsuno, T. Fujiwara, S. Kusaka, M. Uda, J. Matsuoka, Y. Naomoto

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Abstract

A retrospective study was carried out in 110 cadaveric kidney transplant recipients to compare the effects of low doses of cyclosporine (CsA), azathioprine (AZP) and steroids (triple-drug therapy) with those of higher doses of steroids plus AZP (conventional immunosuppression). Graft survival rate in the triple-drug therapy was 77%, 69%, and 69% at 1, 3, and 5 years, respectively. This was significantly better than 48%, 34%, and 29% in conventional immunosuppression. The incidence of acute rejection episodes was significantly lower in the triple-drug therapy than in conventional immunosuppression (25% vs 58%). In conclusion, our study shows that triple-drug therapy using low-dose cyclosporine is the safest of the immunosuppressive regimens and provides a beneficial effect on the long-term survival of cadaveric kidney transplants.

Original languageEnglish
Pages (from-to)53-56
Number of pages4
JournalActa medica Okayama
Volume46
Issue number1
Publication statusPublished - Feb 1992

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ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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