The impact of patatin-like phospholipase domain-containing protein 3 polymorphism on hepatocellular carcinoma prognosis

Yasuto Takeuchi, Fusao Ikeda, Yuki Moritou, Hiroaki Hagihara, Tetsuya Yasunaka, Kenji Kuwaki, Yasuhiro Miyake, Hideki Ohnishi, Shinichiro Nakamura, Hidenori Shiraha, Akinobu Takaki, Yoshiaki Iwasaki, Kazuhiro Nouso, Kazuhide Yamamoto

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Background The single nucleotide polymorphism (SNP) rs738409 in patatin-like phospholipase domain-containing protein 3 (PNPLA3) is associated with hepatic fat accumulation and disease progression in patients with nonalcoholic fatty liver disease and alcoholic liver disease (ALD). This study was conducted to determine whether PNPLA3 rs738409 SNPs affect development and prognosis of hepatocellular carcinoma (HCC) in patients with various liver diseases. Methods We enrolled 638 consecutive Japanese patients newly diagnosed with HCC between 2001 and 2010: 72 patients with hepatitis B virus (HBV), 462 with hepatitis C virus (HCV), and 104 with non-B non-C (NBNC). Results NBNC patients exhibited large tumors of advanced TNM stages at HCC diagnosis, and had significantly poorer prognosis than HBV or HCV patients (P

Original languageEnglish
Pages (from-to)405-412
Number of pages8
JournalJournal of Gastroenterology
Volume48
Issue number3
DOIs
Publication statusPublished - Mar 2013

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Phospholipases
Hepatocellular Carcinoma
Hepatitis B virus
Hepacivirus
Single Nucleotide Polymorphism
Alcoholic Liver Diseases
Disease Progression
Protein Domains
Liver Diseases
Fats
Liver
Neoplasms

Keywords

  • Hepatocellular carcinoma
  • PNPLA3 SNP
  • Survival

ASJC Scopus subject areas

  • Gastroenterology

Cite this

The impact of patatin-like phospholipase domain-containing protein 3 polymorphism on hepatocellular carcinoma prognosis. / Takeuchi, Yasuto; Ikeda, Fusao; Moritou, Yuki; Hagihara, Hiroaki; Yasunaka, Tetsuya; Kuwaki, Kenji; Miyake, Yasuhiro; Ohnishi, Hideki; Nakamura, Shinichiro; Shiraha, Hidenori; Takaki, Akinobu; Iwasaki, Yoshiaki; Nouso, Kazuhiro; Yamamoto, Kazuhide.

In: Journal of Gastroenterology, Vol. 48, No. 3, 03.2013, p. 405-412.

Research output: Contribution to journalArticle

Takeuchi, Yasuto ; Ikeda, Fusao ; Moritou, Yuki ; Hagihara, Hiroaki ; Yasunaka, Tetsuya ; Kuwaki, Kenji ; Miyake, Yasuhiro ; Ohnishi, Hideki ; Nakamura, Shinichiro ; Shiraha, Hidenori ; Takaki, Akinobu ; Iwasaki, Yoshiaki ; Nouso, Kazuhiro ; Yamamoto, Kazuhide. / The impact of patatin-like phospholipase domain-containing protein 3 polymorphism on hepatocellular carcinoma prognosis. In: Journal of Gastroenterology. 2013 ; Vol. 48, No. 3. pp. 405-412.
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AU - Takeuchi, Yasuto

AU - Ikeda, Fusao

AU - Moritou, Yuki

AU - Hagihara, Hiroaki

AU - Yasunaka, Tetsuya

AU - Kuwaki, Kenji

AU - Miyake, Yasuhiro

AU - Ohnishi, Hideki

AU - Nakamura, Shinichiro

AU - Shiraha, Hidenori

AU - Takaki, Akinobu

AU - Iwasaki, Yoshiaki

AU - Nouso, Kazuhiro

AU - Yamamoto, Kazuhide

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AB - Background The single nucleotide polymorphism (SNP) rs738409 in patatin-like phospholipase domain-containing protein 3 (PNPLA3) is associated with hepatic fat accumulation and disease progression in patients with nonalcoholic fatty liver disease and alcoholic liver disease (ALD). This study was conducted to determine whether PNPLA3 rs738409 SNPs affect development and prognosis of hepatocellular carcinoma (HCC) in patients with various liver diseases. Methods We enrolled 638 consecutive Japanese patients newly diagnosed with HCC between 2001 and 2010: 72 patients with hepatitis B virus (HBV), 462 with hepatitis C virus (HCV), and 104 with non-B non-C (NBNC). Results NBNC patients exhibited large tumors of advanced TNM stages at HCC diagnosis, and had significantly poorer prognosis than HBV or HCV patients (P

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