The impact of intraoperative brachytherapy on surgery of Ewing's sarcoma

Toshihumi Ozaki, Axel Hillmann, Christian Rübe, Robert Rödl, Martin Hein, Christiane Hoffmann, Sebastian Blasius, Herbert Jürgens, Winfried Winkelmann

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Abstract

Surgery of Ewing's sarcoma sometimes results in an inadequate surgical margin. The influence of intraoperative brachytherapy on local control of the tumor, operation time, blood loss, and surgical complications was evaluated, comparing the results of 20 patients who received brachytherapy to a series of 42 patients receiving surgery without brachytherapy. The dose of intraoperative brachytherapy ranged between 9 Gy and 21 Gy. The average operation time was longer in 20 cases with brachytherapy (7.9 h) than in 42 cases without brachytherapy (4.3 h) (P <0.0001). The average blood loss in the groups with (3531 ml) and without brachytherapy (3515 ml) was comparable (P = 0.3840). The surgical complication rate in patients receiving brachytherapy was also similar to that of untreated patients (30% versus 31%, P = 0.7690). Local relapse developed in 1 of 20 patients who received brachytherapy and 1 of 42 patients without brachytherapy. On the basis of this analysis, it can be concluded that this procedure is safe and does not increase of the acute complication rate. The latest results of local controls are awaited.

Original languageEnglish
Pages (from-to)53-56
Number of pages4
JournalJournal of Cancer Research and Clinical Oncology
Volume123
Issue number1
Publication statusPublished - 1997
Externally publishedYes

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Keywords

  • Brachytherapy
  • Ewing's sarcoma

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Ozaki, T., Hillmann, A., Rübe, C., Rödl, R., Hein, M., Hoffmann, C., Blasius, S., Jürgens, H., & Winkelmann, W. (1997). The impact of intraoperative brachytherapy on surgery of Ewing's sarcoma. Journal of Cancer Research and Clinical Oncology, 123(1), 53-56.