TY - JOUR
T1 - The impact of intraoperative brachytherapy on surgery of Ewing's sarcoma
AU - Ozaki, Toshifumi
AU - Hillmann, Axel
AU - Rübe, Christian
AU - Rödl, Robert
AU - Hein, Martin
AU - Hoffmann, Christiane
AU - Blasius, Sebastian
AU - Jürgens, Herbert
AU - Winkelmann, Winfried
PY - 1997/1/1
Y1 - 1997/1/1
N2 - Surgery of Ewing's sarcoma sometimes results in an inadequate surgical margin. The influence of intraoperative brachytherapy on local control of the tumor, operation time, blood loss, and surgical complications was evaluated, comparing the results of 20 patients who received brachytherapy to a series of 42 patients receiving surgery without brachytherapy. The dose of intraoperative brachytherapy ranged between 9 Gy and 21 Gy. The average operation time was longer in 20 cases with brachytherapy (7.9 h) than in 42 cases without brachytherapy (4.3 h) (P < 0.0001). The average blood loss in the groups with (3531 ml) and without brachytherapy (3515 ml) was comparable (P = 0.3840). The surgical complication rate in patients receiving brachytherapy was also similar to that of untreated patients (30% versus 31%, P = 0.7690). Local relapse developed in 1 of 20 patients who received brachytherapy and 1 of 42 patients without brachytherapy. On the basis of this analysis, it can be concluded that this procedure is safe and does not increase of the acute complication rate. The latest results of local controls are awaited.
AB - Surgery of Ewing's sarcoma sometimes results in an inadequate surgical margin. The influence of intraoperative brachytherapy on local control of the tumor, operation time, blood loss, and surgical complications was evaluated, comparing the results of 20 patients who received brachytherapy to a series of 42 patients receiving surgery without brachytherapy. The dose of intraoperative brachytherapy ranged between 9 Gy and 21 Gy. The average operation time was longer in 20 cases with brachytherapy (7.9 h) than in 42 cases without brachytherapy (4.3 h) (P < 0.0001). The average blood loss in the groups with (3531 ml) and without brachytherapy (3515 ml) was comparable (P = 0.3840). The surgical complication rate in patients receiving brachytherapy was also similar to that of untreated patients (30% versus 31%, P = 0.7690). Local relapse developed in 1 of 20 patients who received brachytherapy and 1 of 42 patients without brachytherapy. On the basis of this analysis, it can be concluded that this procedure is safe and does not increase of the acute complication rate. The latest results of local controls are awaited.
KW - Brachytherapy
KW - Ewing's sarcoma
UR - http://www.scopus.com/inward/record.url?scp=0031060237&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031060237&partnerID=8YFLogxK
U2 - 10.1007/BF01212615
DO - 10.1007/BF01212615
M3 - Article
C2 - 8996541
AN - SCOPUS:0031060237
VL - 123
SP - 53
EP - 56
JO - Journal of Cancer Research and Clinical Oncology
JF - Journal of Cancer Research and Clinical Oncology
SN - 0171-5216
IS - 1
ER -