The immunosuppressive effects of ciprofloxacin during human mixed lymphocyte reaction

Goutarou Katsuno, Hideo Kohka Takahashi, Hiromi Iwagaki, Kenji Mizuno, Takahito Yagi, Shuji Mori, Shinya Saito, Tadashi Yoshino, Masahiro Nishibori, Noriaki Tanaka

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)

Abstract

Interleukin (IL)-18, which is elevated in the plasma during acute rejection after organ transplantation, is known to induce the expression of intercellular adhesion molecule (ICAM)-1, B7.1, B7.2, CD40 and CD40 ligand (CD40L) on monocytes, the production of interferon (IFN)-γ and IL-12 and the proliferation of lymphocytes during the human mixed lymphocyte reaction (MLR). Ciprofloxacin (CIP), which is useful for the clinical treatment of infections due to its antibacterial properties after transplantation, was shown to suppress the IFN-γ and IL-12 production, the lymphocyte proliferation and the ICAM-1, B7.1, B7.2 and CD40 expression on monocytes during MLR in the presence of IL-18. CIP also induced the production of prostaglandin (PG) E2. In order to determine whether the effects of CIP on the expression of the activation markers were due to CIP-dependent production of PGE2, we examined the effect of cyclooxygenase (COX)-2 and protein kinase A (PKA) inhibitors on the actions of CIP. Thereby, the inhibitors were found to abolish the actions of CIP. These results therefore suggest that CIP might exert its immune modulatory effects via the production of PGE2.

Original languageEnglish
Pages (from-to)110-119
Number of pages10
JournalClinical Immunology
Volume119
Issue number1
DOIs
Publication statusPublished - Apr 2006

Keywords

  • Ciprofloxacin
  • Costimulatory molecule
  • IL-18
  • MLR
  • Prostaglandin

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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