The immunology of atherothrombosis in the antiphospholipid syndrome: Antigen presentation and lipid intracellular accumulation

Eiji Matsuura, Kazuko Kobayashi, Yukana Matsunami, Luis R. Lopez

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

The antiphospholipid syndrome (APS), characterized by elevated serum levels of antiphospholipid antibodies (aPL) and thromboembolic complications, is a common cause of acquired hypercoagulability. The plasma protein β2-glycoprotein I (β2GPI) is the most clinically relevant antigenic target for aPL. Recent experimental evidence from our laboratory substantiated the concept that IgG anti-β2GPI immune complexes containing oxidized LDL (oxLDL) not only facilitated the intracellular accumulation of oxLDL in macrophages but also allowed the presentation of β2GPI epitopes to pathogenic autoreactive T cells. Both mechanisms required FcγRI-mediated uptake by macrophages/monocytes. Furthermore, several clinical studies demonstrated that the presence of circulating oxLDL/β2GPI complexes and IgG autoantibodies to these complexes was significantly associated with vascular inflammation (i.e. autoimmune-mediated atherothrombosis) in autoimmune patients. In this article, we review recent findings concerning the biochemical and immunologic mechanisms involved in autoimmune-mediated atherothrombosis in patients with APS.

Original languageEnglish
Pages (from-to)500-505
Number of pages6
JournalAutoimmunity Reviews
Volume8
Issue number6
DOIs
Publication statusPublished - May 2009

Fingerprint

Antiphospholipid Syndrome
Antigen Presentation
Allergy and Immunology
Glycoproteins
Lipids
Antiphospholipid Antibodies
Macrophages
Thrombophilia
Antigen-Antibody Complex
LDL Lipoproteins
Autoantibodies
Blood Vessels
Blood Proteins
Epitopes
Monocytes
Immunoglobulin G
Inflammation
T-Lymphocytes
Serum
oxidized low density lipoprotein

Keywords

  • β2-glycoprotein I (β2GPI)
  • Antigen presentation
  • Antiphospholipid syndrome (APS)
  • Atherothrombosis
  • Oxidized LDL (oxLDL)

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

The immunology of atherothrombosis in the antiphospholipid syndrome : Antigen presentation and lipid intracellular accumulation. / Matsuura, Eiji; Kobayashi, Kazuko; Matsunami, Yukana; Lopez, Luis R.

In: Autoimmunity Reviews, Vol. 8, No. 6, 05.2009, p. 500-505.

Research output: Contribution to journalArticle

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