The immunological impact of chemotherapy on the tumor microenvironment of oral squamous cell carcinoma

Hiroaki Takakura, Shohei Domae, Toshiro Ono, Akira Sasaki

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Anticancer drugs induce cell-cycle arrest and apoptosis not only in tumor cells, but also in immune cells. However, many preclinical and clinical findings show that some chemotherapeutic agents can improve the antitumor efficacy of immunotherapy. We immunohistochemically analyzed the degree of immune cell infiltration and the relevance of programmed cell death 1 ligand-1 (PD-L1) expression in surgically resected oral squamous cell carcinoma (OSCC) specimens from patients who had undergone pretreatment with certain chemotherapies and other patients without pretreatment. We divided the patients into the group of neoadjuvant chemotherapy (NAC) patients (n=8) and the nNAC (without NAC) patient group (n=10). We observed that NAC induced infiltrations of CD4, CD8 T cells and CD56 NK cells into the tumor microenvironment. Decreased numbers of Tregs and PD-1-positive cells were observed in the NAC group. No significant difference was observed in the degree of immune-cell infiltration between the patient groups except for CD56 NK cells in the stroma and PD-1 cells in cancer nests. Eighty percent of the nNAC specimens showed intermediate-to-strong PD-L1 protein expression, whereas 75% of the NAC specimens showed down-regulation of the PD-L1 protein, indicating the effectiveness of the chemotherapeutic treatment before surgery.

Original languageEnglish
Pages (from-to)219-226
Number of pages8
JournalActa Medica Okayama
Volume71
Issue number3
Publication statusPublished - 2017

Fingerprint

Tumor Microenvironment
Chemotherapy
CD274 Antigen
Tumors
Squamous Cell Carcinoma
Drug Therapy
Infiltration
Cells
Natural Killer Cells
T-cells
Cell Cycle Checkpoints
Immunotherapy
Surgery
Epithelial Cells
Neoplasms
Down-Regulation
Apoptosis
T-Lymphocytes
Pharmaceutical Preparations

Keywords

  • Immunohistochemistry
  • Neoadjuvant chemotherapy
  • Oral squamous cell carcinoma
  • Programmed cell death 1 ligand-1
  • Tumor microenvironment

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

The immunological impact of chemotherapy on the tumor microenvironment of oral squamous cell carcinoma. / Takakura, Hiroaki; Domae, Shohei; Ono, Toshiro; Sasaki, Akira.

In: Acta Medica Okayama, Vol. 71, No. 3, 2017, p. 219-226.

Research output: Contribution to journalArticle

Takakura, Hiroaki ; Domae, Shohei ; Ono, Toshiro ; Sasaki, Akira. / The immunological impact of chemotherapy on the tumor microenvironment of oral squamous cell carcinoma. In: Acta Medica Okayama. 2017 ; Vol. 71, No. 3. pp. 219-226.
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