Abstract
Stage classification is an important underpinning of management of patients with cancer, and rests on a combination of three components: T for tumor extent, N for nodal involvement, and M for more distant metastases. This article details an initiative to develop proposals for the first official stage classification system for thymic malignancies for the 8th edition of the stage classification manuals. Specifically, the results of analysis of a large database and the considerations leading to the proposed N and M components are described. Nodal involvement is divided into an anterior (N1) and a deep (N2) category. Metastases can involve pleural or pericardial nodules (M1a) or intraparenchymal pulmonary nodules or metastases to distant sites (M1b).
| Original language | English |
|---|---|
| Pages (from-to) | S81-S87 |
| Journal | Journal of Thoracic Oncology |
| Volume | 9 |
| Issue number | 9 |
| Publication status | Published - 2014 |
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Keywords
- Prognosis
- Stage classification
- Staging
- Thymic carcinoma
- Thymoma
ASJC Scopus subject areas
- Oncology
- Pulmonary and Respiratory Medicine
Cite this
The IASLC/ITMIG thymic epithelial tumors staging project : Proposals for the N and M components for the forthcoming (8th) edition of the TNM classification of malignant tumors. / Kondo, Kazuya; Van Schil, Paul; Detterbeck, Frank C.; Okumura, Meinoshin; Giroux, Dorothy; Asamura, Hisao; Crowley, John; Falkson, Conrad; Filosso, Pier Luigi; Giaccone, Giuseppe; Huang, James; Kim, Jhingook; Lucchi, Marco; Marino, Mirella; Marom, Edith M.; Nicholson, Andrew G.; Ruffini, Enrico; Goldstraw, Peter; Rami-Porta, Ramón; Ball, David; Beer, David; Beyruti, Ricardo; Bolejack, Vanessa; Chansky, Kari; Eberhardt, Wilfried Ernst Erich; Edwards, John; Galateau-Sallé, Françoise; Gleeson, Fergus; Groome, Patti; Kennedy, Catherine; Kingsbury, Laura; Kim, Young Tae; Kondo, Haruhiko; Krasnik, Mark; Kubota, Kaoru; Lerut, Antoon; Lyons, Gustavo; Van Meerbeeck, Jan; Mitchell, Alan; Nakano, Takashi; Nowak, Anna; Peake, Michael; Rice, Thomas; Rosenzweig, Kenneth; Rusch, Valerie; Saijo, Nagahiro; Sculier, Jean Paul; Shemanski, Lynn; Stratton, Kelly; Suzuki, Kenji; Tachimori, Yuji; Thomas, Charles F.; Travis, William; Tsao, Ming S.; Turrisi, Andrew; Vansteenkiste, Johan; Watanabe, Hirokazu; Wu, Yi Long; Baas, Paul; Erasmus, Jeremy; Hasegawa, Seiki; Inai, Kouki; Kernstine, Kemp; Kindler, Hedy; Krug, Lee; Nackaerts, Kristiaan; Pass, Harvey; Rice, David; Blackstone, Eugene; Call Caja, S.; Ahmad, U.; Detterbeck, F.; Girard, N.; Haam, Seok Jin; Gomez, D. R.; Marom, E. M.; Van Schil, P.; Bae, Mi Kyung; Gomez, D. R.; Marom, E. M.; Van Schil, P.; Ströbel, P.; Marx, A.; Saita, S.; Wakelee, H.; Bertolaccini, L.; Vallieres, E.; Scott, W.; Su, S.; Park, B.; Marks, J.; Khella, S.; Shen, R.; Rosenberg, M.; Rosenberg, M.; Huang, J.; Tomulescu, V.; Foroulis, C.; Lang-Lazdunski, L.; Billè, Andrea; Maessen, J. G.; Keijzers, M.; Van Veer, H.; Wright, C.; Facciolo, F.; Palmieri, G.; Buonerba, C.; Ferguson, M.; Marulli, G.; Loehrer, P.; Kalkat, M.; Rohrberg, K.; Daugaard, G.; Toker, A.; Erus, S.; Kimmich, M.; Brunelli, A.; Refai, M.; Nicholson, A.; Lim, E.; Park, In Kyu; Wagner, J.; Tieu, B.; Fang, Wentao; Zhang, Jie; Yu, Zhentao; Han, Yongtao; Li, Yin; Chen, Keneng; Chen, Gang; Nagai, Kanji; Fujii, Yoshitaka; Nakajima, Jun; Ikeda, Norihiko; Haraguchi, Shuji; Onuki, Takamasa; Yoshino, Ichiro; Tsuchida, Masanori; Takahashi, Shoji; Yokoi, Kohei; Hanyuda, Masayuki; Niwa, Hiroshi; Date, Hiroshi; Maniwa, Yoshimasa; Miyoshi, Shinichiro; Iwasaki, Akinori; Okamoto, Tatsuro; Nagayasu, Takeshi; Tanaka, Fumihiro; Suzuki, Minoru; Yoshida, Kazuo; Okuma, Yusuke; Horio, Hirotoshi; Matsumura, Akihide; Higashiyama, Masahiko; Suehisa, Hiroshi; Onuki, Takuya; Sano, Yoshifumi; Kondo, Keishi; Al Kattan, K.; Cerfolio, R.; Gebitekin, C.; Gomez De Antonio, D.; Kernstine, K. H.; Altorki, N.; Novoa, N.; Ruffini, E.; Filosso, P. L.; Saita, S.; Scarci, M.; Voltolini, L.; Weder, W.; Zurek, Wojciech; Arame, A.; Casadio, C.; Carbognani, P.; Donati, G.; Keshavjee, S.; Klepetko, W.; Moser, B.; Lequaglie, C.; Liberman, Moishe; Mancuso, M.; Nosotti, M.; Spaggiari, L.; Thomas, P. A.; Rendina, E.; Venuta, F.; Anile, M.; Schützner, J.; Rocco, G.
In: Journal of Thoracic Oncology, Vol. 9, No. 9, 2014, p. S81-S87.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The IASLC/ITMIG thymic epithelial tumors staging project
T2 - Proposals for the N and M components for the forthcoming (8th) edition of the TNM classification of malignant tumors
AU - Kondo, Kazuya
AU - Van Schil, Paul
AU - Detterbeck, Frank C.
AU - Okumura, Meinoshin
AU - Giroux, Dorothy
AU - Asamura, Hisao
AU - Crowley, John
AU - Falkson, Conrad
AU - Filosso, Pier Luigi
AU - Giaccone, Giuseppe
AU - Huang, James
AU - Kim, Jhingook
AU - Lucchi, Marco
AU - Marino, Mirella
AU - Marom, Edith M.
AU - Nicholson, Andrew G.
AU - Ruffini, Enrico
AU - Goldstraw, Peter
AU - Rami-Porta, Ramón
AU - Ball, David
AU - Beer, David
AU - Beyruti, Ricardo
AU - Bolejack, Vanessa
AU - Chansky, Kari
AU - Eberhardt, Wilfried Ernst Erich
AU - Edwards, John
AU - Galateau-Sallé, Françoise
AU - Gleeson, Fergus
AU - Groome, Patti
AU - Kennedy, Catherine
AU - Kingsbury, Laura
AU - Kim, Young Tae
AU - Kondo, Haruhiko
AU - Krasnik, Mark
AU - Kubota, Kaoru
AU - Lerut, Antoon
AU - Lyons, Gustavo
AU - Van Meerbeeck, Jan
AU - Mitchell, Alan
AU - Nakano, Takashi
AU - Nowak, Anna
AU - Peake, Michael
AU - Rice, Thomas
AU - Rosenzweig, Kenneth
AU - Rusch, Valerie
AU - Saijo, Nagahiro
AU - Sculier, Jean Paul
AU - Shemanski, Lynn
AU - Stratton, Kelly
AU - Suzuki, Kenji
AU - Tachimori, Yuji
AU - Thomas, Charles F.
AU - Travis, William
AU - Tsao, Ming S.
AU - Turrisi, Andrew
AU - Vansteenkiste, Johan
AU - Watanabe, Hirokazu
AU - Wu, Yi Long
AU - Baas, Paul
AU - Erasmus, Jeremy
AU - Hasegawa, Seiki
AU - Inai, Kouki
AU - Kernstine, Kemp
AU - Kindler, Hedy
AU - Krug, Lee
AU - Nackaerts, Kristiaan
AU - Pass, Harvey
AU - Rice, David
AU - Blackstone, Eugene
AU - Call Caja, S.
AU - Ahmad, U.
AU - Detterbeck, F.
AU - Girard, N.
AU - Haam, Seok Jin
AU - Gomez, D. R.
AU - Marom, E. M.
AU - Van Schil, P.
AU - Bae, Mi Kyung
AU - Gomez, D. R.
AU - Marom, E. M.
AU - Van Schil, P.
AU - Ströbel, P.
AU - Marx, A.
AU - Saita, S.
AU - Wakelee, H.
AU - Bertolaccini, L.
AU - Vallieres, E.
AU - Scott, W.
AU - Su, S.
AU - Park, B.
AU - Marks, J.
AU - Khella, S.
AU - Shen, R.
AU - Rosenberg, M.
AU - Rosenberg, M.
AU - Huang, J.
AU - Tomulescu, V.
AU - Foroulis, C.
AU - Lang-Lazdunski, L.
AU - Billè, Andrea
AU - Maessen, J. G.
AU - Keijzers, M.
AU - Van Veer, H.
AU - Wright, C.
AU - Facciolo, F.
AU - Palmieri, G.
AU - Buonerba, C.
AU - Ferguson, M.
AU - Marulli, G.
AU - Loehrer, P.
AU - Kalkat, M.
AU - Rohrberg, K.
AU - Daugaard, G.
AU - Toker, A.
AU - Erus, S.
AU - Kimmich, M.
AU - Brunelli, A.
AU - Refai, M.
AU - Nicholson, A.
AU - Lim, E.
AU - Park, In Kyu
AU - Wagner, J.
AU - Tieu, B.
AU - Fang, Wentao
AU - Zhang, Jie
AU - Yu, Zhentao
AU - Han, Yongtao
AU - Li, Yin
AU - Chen, Keneng
AU - Chen, Gang
AU - Nagai, Kanji
AU - Fujii, Yoshitaka
AU - Nakajima, Jun
AU - Ikeda, Norihiko
AU - Haraguchi, Shuji
AU - Onuki, Takamasa
AU - Yoshino, Ichiro
AU - Tsuchida, Masanori
AU - Takahashi, Shoji
AU - Yokoi, Kohei
AU - Hanyuda, Masayuki
AU - Niwa, Hiroshi
AU - Date, Hiroshi
AU - Maniwa, Yoshimasa
AU - Miyoshi, Shinichiro
AU - Iwasaki, Akinori
AU - Okamoto, Tatsuro
AU - Nagayasu, Takeshi
AU - Tanaka, Fumihiro
AU - Suzuki, Minoru
AU - Yoshida, Kazuo
AU - Okuma, Yusuke
AU - Horio, Hirotoshi
AU - Matsumura, Akihide
AU - Higashiyama, Masahiko
AU - Suehisa, Hiroshi
AU - Onuki, Takuya
AU - Sano, Yoshifumi
AU - Kondo, Keishi
AU - Al Kattan, K.
AU - Cerfolio, R.
AU - Gebitekin, C.
AU - Gomez De Antonio, D.
AU - Kernstine, K. H.
AU - Altorki, N.
AU - Novoa, N.
AU - Ruffini, E.
AU - Filosso, P. L.
AU - Saita, S.
AU - Scarci, M.
AU - Voltolini, L.
AU - Weder, W.
AU - Zurek, Wojciech
AU - Arame, A.
AU - Casadio, C.
AU - Carbognani, P.
AU - Donati, G.
AU - Keshavjee, S.
AU - Klepetko, W.
AU - Moser, B.
AU - Lequaglie, C.
AU - Liberman, Moishe
AU - Mancuso, M.
AU - Nosotti, M.
AU - Spaggiari, L.
AU - Thomas, P. A.
AU - Rendina, E.
AU - Venuta, F.
AU - Anile, M.
AU - Schützner, J.
AU - Rocco, G.
PY - 2014
Y1 - 2014
N2 - Stage classification is an important underpinning of management of patients with cancer, and rests on a combination of three components: T for tumor extent, N for nodal involvement, and M for more distant metastases. This article details an initiative to develop proposals for the first official stage classification system for thymic malignancies for the 8th edition of the stage classification manuals. Specifically, the results of analysis of a large database and the considerations leading to the proposed N and M components are described. Nodal involvement is divided into an anterior (N1) and a deep (N2) category. Metastases can involve pleural or pericardial nodules (M1a) or intraparenchymal pulmonary nodules or metastases to distant sites (M1b).
AB - Stage classification is an important underpinning of management of patients with cancer, and rests on a combination of three components: T for tumor extent, N for nodal involvement, and M for more distant metastases. This article details an initiative to develop proposals for the first official stage classification system for thymic malignancies for the 8th edition of the stage classification manuals. Specifically, the results of analysis of a large database and the considerations leading to the proposed N and M components are described. Nodal involvement is divided into an anterior (N1) and a deep (N2) category. Metastases can involve pleural or pericardial nodules (M1a) or intraparenchymal pulmonary nodules or metastases to distant sites (M1b).
KW - Prognosis
KW - Stage classification
KW - Staging
KW - Thymic carcinoma
KW - Thymoma
UR - http://www.scopus.com/inward/record.url?scp=84949117731&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84949117731&partnerID=8YFLogxK
M3 - Article
VL - 9
SP - S81-S87
JO - Journal of Thoracic Oncology
JF - Journal of Thoracic Oncology
SN - 1556-0864
IS - 9
ER -