The IASLC/ITMIG thymic epithelial tumors staging project: Proposals for the N and M components for the forthcoming (8th) edition of the TNM classification of malignant tumors

Kazuya Kondo, Paul Van Schil, Frank C. Detterbeck, Meinoshin Okumura, Dorothy Giroux, Hisao Asamura, John Crowley, Conrad Falkson, Pier Luigi Filosso, Giuseppe Giaccone, James Huang, Jhingook Kim, Marco Lucchi, Mirella Marino, Edith M. Marom, Andrew G. Nicholson, Enrico Ruffini, Peter Goldstraw, Ramón Rami-Porta, David BallDavid Beer, Ricardo Beyruti, Vanessa Bolejack, Kari Chansky, Wilfried Ernst Erich Eberhardt, John Edwards, Françoise Galateau-Sallé, Fergus Gleeson, Patti Groome, Catherine Kennedy, Laura Kingsbury, Young Tae Kim, Haruhiko Kondo, Mark Krasnik, Kaoru Kubota, Antoon Lerut, Gustavo Lyons, Jan Van Meerbeeck, Alan Mitchell, Takashi Nakano, Anna Nowak, Michael Peake, Thomas Rice, Kenneth Rosenzweig, Valerie Rusch, Nagahiro Saijo, Jean Paul Sculier, Lynn Shemanski, Kelly Stratton, Kenji Suzuki, Yuji Tachimori, Charles F. Thomas, William Travis, Ming S. Tsao, Andrew Turrisi, Johan Vansteenkiste, Hirokazu Watanabe, Yi Long Wu, Paul Baas, Jeremy Erasmus, Seiki Hasegawa, Kouki Inai, Kemp Kernstine, Hedy Kindler, Lee Krug, Kristiaan Nackaerts, Harvey Pass, David Rice, Eugene Blackstone, S. Call Caja, U. Ahmad, F. Detterbeck, N. Girard, Seok Jin Haam, D. R. Gomez, E. M. Marom, P. Van Schil, Mi Kyung Bae, D. R. Gomez, E. M. Marom, P. Van Schil, P. Ströbel, A. Marx, S. Saita, H. Wakelee, L. Bertolaccini, E. Vallieres, W. Scott, S. Su, B. Park, J. Marks, S. Khella, R. Shen, M. Rosenberg, M. Rosenberg, J. Huang, V. Tomulescu, C. Foroulis, L. Lang-Lazdunski, Andrea Billè, J. G. Maessen, M. Keijzers, H. Van Veer, C. Wright, F. Facciolo, G. Palmieri, C. Buonerba, M. Ferguson, G. Marulli, P. Loehrer, M. Kalkat, K. Rohrberg, G. Daugaard, A. Toker, S. Erus, M. Kimmich, A. Brunelli, M. Refai, A. Nicholson, E. Lim, In Kyu Park, J. Wagner, B. Tieu, Wentao Fang, Jie Zhang, Zhentao Yu, Yongtao Han, Yin Li, Keneng Chen, Gang Chen, Kanji Nagai, Yoshitaka Fujii, Jun Nakajima, Norihiko Ikeda, Shuji Haraguchi, Takamasa Onuki, Ichiro Yoshino, Masanori Tsuchida, Shoji Takahashi, Kohei Yokoi, Masayuki Hanyuda, Hiroshi Niwa, Hiroshi Date, Yoshimasa Maniwa, Shinichiro Miyoshi, Akinori Iwasaki, Tatsuro Okamoto, Takeshi Nagayasu, Fumihiro Tanaka, Minoru Suzuki, Kazuo Yoshida, Yusuke Okuma, Hirotoshi Horio, Akihide Matsumura, Masahiko Higashiyama, Hiroshi Suehisa, Takuya Onuki, Yoshifumi Sano, Keishi Kondo, K. Al Kattan, R. Cerfolio, C. Gebitekin, D. Gomez De Antonio, K. H. Kernstine, N. Altorki, N. Novoa, E. Ruffini, P. L. Filosso, S. Saita, M. Scarci, L. Voltolini, W. Weder, Wojciech Zurek, A. Arame, C. Casadio, P. Carbognani, G. Donati, S. Keshavjee, W. Klepetko, B. Moser, C. Lequaglie, Moishe Liberman, M. Mancuso, M. Nosotti, L. Spaggiari, P. A. Thomas, E. Rendina, F. Venuta, M. Anile, J. Schützner, G. Rocco

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Abstract

Stage classification is an important underpinning of management of patients with cancer, and rests on a combination of three components: T for tumor extent, N for nodal involvement, and M for more distant metastases. This article details an initiative to develop proposals for the first official stage classification system for thymic malignancies for the 8th edition of the stage classification manuals. Specifically, the results of analysis of a large database and the considerations leading to the proposed N and M components are described. Nodal involvement is divided into an anterior (N1) and a deep (N2) category. Metastases can involve pleural or pericardial nodules (M1a) or intraparenchymal pulmonary nodules or metastases to distant sites (M1b).

Original languageEnglish
Pages (from-to)S81-S87
JournalJournal of Thoracic Oncology
Volume9
Issue number9
Publication statusPublished - 2014

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Keywords

  • Prognosis
  • Stage classification
  • Staging
  • Thymic carcinoma
  • Thymoma

ASJC Scopus subject areas

  • Oncology
  • Pulmonary and Respiratory Medicine

Cite this

Kondo, K., Van Schil, P., Detterbeck, F. C., Okumura, M., Giroux, D., Asamura, H., Crowley, J., Falkson, C., Filosso, P. L., Giaccone, G., Huang, J., Kim, J., Lucchi, M., Marino, M., Marom, E. M., Nicholson, A. G., Ruffini, E., Goldstraw, P., Rami-Porta, R., ... Rocco, G. (2014). The IASLC/ITMIG thymic epithelial tumors staging project: Proposals for the N and M components for the forthcoming (8th) edition of the TNM classification of malignant tumors. Journal of Thoracic Oncology, 9(9), S81-S87.