The hyaluronan and proteoglycan link proteins: Organizers of the brain extracellular matrix and key molecules for neuronal function and plasticity

Toshitaka Oohashi, Midori Edamatsu, Yoko Bekku, Daniela Carulli

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

The hyaluronan and proteoglycanbinding link protei. n (Hapln) is a key molecule in the formation and control of hyaluronan-based condensed perineuronal matrix in the adult brain. This review summarizes the recent advances in understanding the role of Haplns in the formation and control of two distinct types of perineuronal matrices, one for "classical" PNN and the other for the specialized extracellular matrix (ECM) at the node of Ranvier in the central nervous system (CNS). We introduce the structural components of each ECM organization including the basic concept of supramolecular structure named "HLT model". We furthermore summarize the developmental and physiological role of perineuronal ECMs from the studies of Haplns and related molecules. Finally, we also discuss the potential mechanism modulating PNNs in the adult CNS. This layer of organized matrices may exert a direct effect via core protein or sugar moiety from the structure or by acting as a binding site for biologically active molecules, which are important for neuronal plasticity and saltatory conduction.

Original languageEnglish
Pages (from-to)134-144
Number of pages11
JournalExperimental Neurology
Volume274
DOIs
Publication statusPublished - Dec 1 2015

Fingerprint

Neuronal Plasticity
Proteoglycans
Hyaluronic Acid
Extracellular Matrix
Central Nervous System
Ranvier's Nodes
Proteus
Brain
Binding Sites
Proteins
link protein

Keywords

  • Hyaluronan
  • Link protein
  • Node of Ranvier
  • Perineuronal net
  • Plasticity
  • Proteoglycan
  • Saltatory conduction

ASJC Scopus subject areas

  • Neurology
  • Developmental Neuroscience

Cite this

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abstract = "The hyaluronan and proteoglycanbinding link protei. n (Hapln) is a key molecule in the formation and control of hyaluronan-based condensed perineuronal matrix in the adult brain. This review summarizes the recent advances in understanding the role of Haplns in the formation and control of two distinct types of perineuronal matrices, one for {"}classical{"} PNN and the other for the specialized extracellular matrix (ECM) at the node of Ranvier in the central nervous system (CNS). We introduce the structural components of each ECM organization including the basic concept of supramolecular structure named {"}HLT model{"}. We furthermore summarize the developmental and physiological role of perineuronal ECMs from the studies of Haplns and related molecules. Finally, we also discuss the potential mechanism modulating PNNs in the adult CNS. This layer of organized matrices may exert a direct effect via core protein or sugar moiety from the structure or by acting as a binding site for biologically active molecules, which are important for neuronal plasticity and saltatory conduction.",
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