The human bitter taste receptor hTAS2R39 is the primary receptor for the bitterness of theaflavins

Toyomi Yamazaki, Miki Sagisaka, Riko Ikeda, Toshiyuki Nakamura, Noriko Matsuda, Takeshi Ishii, Tsutomu Nakayama, Tatsuo Watanabe

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

We purified several hundred mgs of four major theaflavins (theaflavin, theaflavin-3-O-gallate, theaflavin-3′-O-gallate, and theaflavin-3,3′-O-digallate). Among the 25 hTAS2Rs expressed in HEK293T cells, hTAS2R39 and hTAS2R14 were activated by theaflavins. Both hTAS2R39 and hTAS2R14 responded to theaflavin-3′-O-gallate. In addition, hTAS2R39 was activated by theaflavin and theaflavin-3,3′-O-gallate, but not by theaflavin-3-O-gallate. In contrast, hTAS2R14 responded to theaflavin-3-O-gallate.

Original languageEnglish
Pages (from-to)1753-1756
Number of pages4
JournalBioscience, Biotechnology and Biochemistry
Volume78
Issue number10
DOIs
Publication statusPublished - Jan 1 2014
Externally publishedYes

Keywords

  • Human bitter taste receptor
  • Human bitter taste receptor 14 (hTAS2R14)
  • Human bitter taste receptor 39 (hTAS2R39)
  • Theaflavins

ASJC Scopus subject areas

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

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