The gut microbiome of healthy Japanese and its microbial and functional uniqueness

Suguru Nishijima, Wataru Suda, Kenshiro Oshima, Seok Won Kim, Yuu Hirose, Hidetoshi Morita, Masahira Hattori

Research output: Contribution to journalArticle

74 Citations (Scopus)

Abstract

The human gut microbiome has profound influences on the host's health largely through its interference with various intestinal functions. As recent studies have suggested diversity in the human gut microbiome among human populations, it will be interesting to analyse how gut microbiome is correlated with geographical, cultural, and traditional differences. The Japanese people are known to have several characteristic features such as eating a variety of traditional foods and exhibiting a low BMI and long life span. In this study, we analysed gut microbiomes of the Japanese by comparing the metagenomic data obtained from 106 Japanese individuals with those from 11 other nations. We found that the composition of the Japanese gut microbiome showed more abundant in the phylum Actinobacteria, in particular in the genus Bifidobacterium, than other nations. Regarding the microbial functions, those of carbohydrate metabolism were overrepresented with a concurrent decrease in those for replication and repair, and cell motility. The remarkable low prevalence of genes for methanogenesis with a significant depletion of the archaeon Methanobrevibacter smithii and enrichment of acetogenesis genes in the Japanese gut microbiome compared with others suggested a difference in the hydrogen metabolism pathway in the gut between them. It thus seems that the gut microbiome of the Japanese is considerably different from those of other populations, which cannot be simply explained by diet alone. We postulate possible existence of hitherto unknown factors contributing to the population-level diversity in human gut microbiomes.

Original languageEnglish
Pages (from-to)125-133
Number of pages9
JournalDNA Research
Volume23
Issue number2
DOIs
Publication statusPublished - Apr 1 2016

Fingerprint

Microbiota
Methanobrevibacter
Population
Metagenomics
Bifidobacterium
Gastrointestinal Microbiome
Actinobacteria
Archaea
Carbohydrate Metabolism
Genes
Cell Movement
Hydrogen
Eating
Diet
Food
Health

Keywords

  • gut
  • Japanese
  • metagenome
  • microbiome

ASJC Scopus subject areas

  • Genetics
  • Molecular Biology

Cite this

Nishijima, S., Suda, W., Oshima, K., Kim, S. W., Hirose, Y., Morita, H., & Hattori, M. (2016). The gut microbiome of healthy Japanese and its microbial and functional uniqueness. DNA Research, 23(2), 125-133. https://doi.org/10.1093/dnares/dsw002

The gut microbiome of healthy Japanese and its microbial and functional uniqueness. / Nishijima, Suguru; Suda, Wataru; Oshima, Kenshiro; Kim, Seok Won; Hirose, Yuu; Morita, Hidetoshi; Hattori, Masahira.

In: DNA Research, Vol. 23, No. 2, 01.04.2016, p. 125-133.

Research output: Contribution to journalArticle

Nishijima, S, Suda, W, Oshima, K, Kim, SW, Hirose, Y, Morita, H & Hattori, M 2016, 'The gut microbiome of healthy Japanese and its microbial and functional uniqueness', DNA Research, vol. 23, no. 2, pp. 125-133. https://doi.org/10.1093/dnares/dsw002
Nishijima, Suguru ; Suda, Wataru ; Oshima, Kenshiro ; Kim, Seok Won ; Hirose, Yuu ; Morita, Hidetoshi ; Hattori, Masahira. / The gut microbiome of healthy Japanese and its microbial and functional uniqueness. In: DNA Research. 2016 ; Vol. 23, No. 2. pp. 125-133.
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