The glycine transporter 1 gene (GLYT1) is associated with methamphetamine-use disorder

Yukitaka Morita, Hiroshi Ujike, Yuji Tanaka, Makiko Kishimoto, Yuko Okahisa, Tatsuya Kotaka, Mutsuo Harano, Toshiya Inada, Tokutaro Komiyama, Toru Hori, Mitsuhiko Yamada, Yoshimoto Sekine, Nakao Iwata, Masaomi Iyo, Ichiro Sora, Norio Ozaki, Shigetoshi Kuroda

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Glycine transporter (GlyT)-1 plays a pivotal role in maintaining the glycine level at the glutamatergic synapse. Glycine is an allosteric agonist of N-methyl-D-aspartate (NMDA) receptors. Because activation of NMDA receptors is an essential step for induction of methamphetamine dependence and psychosis, differences in the functioning of GlyT-1 due to genetic variants of the GlyT-1 gene (GLYT1) may influence susceptibility. A case-control genetic association study of the GLYT1 gene examined 204 patients with methamphetamine-use disorder and 210 healthy controls. We examined three single nucleotide polymorphisms (SNPs), SNP1, IVS3 + 411C > T, rs2486001; SNP2, 1056G > A, rs2248829; and SNP3, IVS11 + 22G > A, rs2248632, of the GLYT1 gene and found that SNP1 showed a significant association in both genotype (P = 0.0086) and allele (P = 0.0019) with methamphetamine-use disorder. The T-G haplotype at SNP1 and SNP2 was a significant risk factor for the disorder (P = 0.000039, odds ratio: 2.04). The present findings indicate that genetic variation of the GLYT1 gene may contribute to individual vulnerability to methamphetamine dependence and psychosis.

Original languageEnglish
Pages (from-to)54-58
Number of pages5
JournalAmerican Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
Volume147
Issue number1
DOIs
Publication statusPublished - Jan 5 2008

Keywords

  • Association study
  • Glycine transporter (GlyT)
  • Substance dependence

ASJC Scopus subject areas

  • Genetics(clinical)
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience

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    Morita, Y., Ujike, H., Tanaka, Y., Kishimoto, M., Okahisa, Y., Kotaka, T., Harano, M., Inada, T., Komiyama, T., Hori, T., Yamada, M., Sekine, Y., Iwata, N., Iyo, M., Sora, I., Ozaki, N., & Kuroda, S. (2008). The glycine transporter 1 gene (GLYT1) is associated with methamphetamine-use disorder. American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics, 147(1), 54-58. https://doi.org/10.1002/ajmg.b.30565