The Ginkgo biloba extract (EGb 761) provides a neuroprotective effect on retinal ganglion cells in a rat model of chronic glaucoma

Kazuyuki Hirooka, Masaaki Tokuda, Osamu Miyamoto, Toshifumi Itano, Tetsuya Baba, Fumio Shiraga

Research output: Contribution to journalArticle

59 Citations (Scopus)

Abstract

Purpose. To investigate the effect of Ginkgo biloba extract (EGb 761) against neurotoxicity of retinal ganglion cells of rats with chronic moderately elevated intraocular pressure (IOP). Methods. Unilateral chronic moderately elevated IOP was produced in rats by cautery of three episcleral vessels. Secondary degeneration was measured with and without EGb 761 for 5 months. At 5 months, retinal ganglion cells were labeled with a fast blue tracer applied to both superior colliculi. Densities of surviving retinal ganglion cells were estimated by counting fast blue labeled cells in whole mounted retinas. Results. When compared with their contralateral control eyes with normal IOP, in the peripheral retina, retinal ganglion cell loss in eyes with chronic, moderately elevated IOP was 29.8 ± 1.5% (n = 5) at 5 months in untreated animals and 4.6 ± 4.5% (n = 5) at 5 months in treated animals with EGb 761. Conclusions. Pretreatment and early posttreatment with EGb 761 is an effective neuroprotectant in a rat model of chronic glaucoma.

Original languageEnglish
Pages (from-to)153-157
Number of pages5
JournalCurrent Eye Research
Volume28
Issue number3
DOIs
Publication statusPublished - Mar 1 2004
Externally publishedYes

Keywords

  • Ganglion cell
  • Glaucoma
  • Glaucoma pharmacology
  • Intraocular pressure
  • Nitric oxide

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

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