The genotoxicity of N-aminocytidine in the drosophila wing spot test

Tomoe Negishi, Kazuo Negishi, Haruko Ryo, Sohei Kondo, Hikoya Hayatsu

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The nucleoside analogue N4-aminocytidine is known to induce mutations in bacteria, and was shown to induce somatic mutations in Drosophila melanogaster after larval administration. The assay system employed was a wing-hair mutation spot test developed by Würgler and co-workers. The potency of N4-aminocytidine to induce somatic mutation is comparable to those of several food-pyrolysate mutagens previously reported. The occurrence of twin spots, i.e. two types of recessive mutant-hair clones in adjacent positions, suggests that N4-aminocytidine induces somatic recombination in Drosophila. Another feature of the mutagenicity of N4-aminocytidine is that both the acute and the chronic larval feedings gave rise to mutant hair formation of similar patterns with respect to the spot-size distributions: small single spots were formed predominantly and the larger the spotsize, the lower their frequency.

Original languageEnglish
Pages (from-to)11-13
Number of pages3
JournalMutagenesis
Volume3
Issue number1
DOIs
Publication statusPublished - Jan 1 1988

ASJC Scopus subject areas

  • Genetics
  • Toxicology
  • Genetics(clinical)
  • Health, Toxicology and Mutagenesis

Fingerprint Dive into the research topics of 'The genotoxicity of N-aminocytidine in the drosophila wing spot test'. Together they form a unique fingerprint.

  • Cite this

    Negishi, T., Negishi, K., Ryo, H., Kondo, S., & Hayatsu, H. (1988). The genotoxicity of N-aminocytidine in the drosophila wing spot test. Mutagenesis, 3(1), 11-13. https://doi.org/10.1093/mutage/3.1.11