The G-protein coupled chemoattractant receptor FPR2 promotes malignant phenotype of human colon cancer cells

Yi Xiang, Xiaohong Yao, Keqiang Chen, Xiafei Wang, Jiamin Zhou, Wanghua Gong, Teizo Yoshimura, Jiaqiang Huang, Rongquan Wang, Yuzhang Wu, Guochao Shi, Xiuwu Bian, Jiming Wang

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

The G-protein coupled chemoattractant receptor formylpeptide receptor-2 (FPR2 in human, Fpr2 in mice) is expressed by mouse colon epithelial cells and plays a critical role in mediating mucosal homeostasis and inflammatory responses. However, the biological role of FPR2 in human colon is unclear. Our investigation revealed that a considerable number of human colon cancer cell lines expressed FPR2 and its ligands promoted cell migration and proliferation. Human colon cancer cell lines expressing high levels of FPR2 also formed more rapidly growing tumors in immunocompromised mice as compared with cell lines expressing lower levels of FPR2. Knocking down of FPR2 from colon cancer cell lines highly expressing FPR2 reduced their tumorigenicity. Clinically, FPR2 is more highly expressed in progressive colon cancer, associated with poorer patient prognosis. These results suggest that FPR2 can be high-jacked by colon cancer cells for their growth advantage, thus becoming a potential target for therapeutic development.

Original languageEnglish
Pages (from-to)2599-2610
Number of pages12
JournalAmerican Journal of Cancer Research
Volume6
Issue number11
Publication statusPublished - 2016
Externally publishedYes

Keywords

  • Cancer
  • Colon
  • FPR2
  • Prognosis
  • Tumorigenesis

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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