The function of dynamin in endocytosis

Pietro De Camilli, Kohji Takei, Peter S. McPherson

Research output: Contribution to journalArticle

126 Citations (Scopus)

Abstract

Temperature-sensitive shibire mutants of Drosophila melanogaster become rapidly paralyzed upon a shift to the restrictive temperature, which is due to a block in synaptic vesicle endocytosis. The shibire gene encodes the GTPase dynamin. Recent studies have shown that dynamin forms rings at the neck of invaginated clathrin-coated pits, and have suggested that a conformational change in the ring, which correlates with GTP hydrolysis, plays an essential role in vesicle fission.

Original languageEnglish
Pages (from-to)559-565
Number of pages7
JournalCurrent Opinion in Neurobiology
Volume5
Issue number5
DOIs
Publication statusPublished - 1995
Externally publishedYes

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ASJC Scopus subject areas

  • Neuroscience(all)

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