TY - JOUR
T1 - The frequency of postoperative BNP measurement and intervention threshold of BNP concentration in pediatric cardiac intensive care unit
T2 - a prospective multicenter observational study
AU - Kanazawa, Tomoyuki
AU - Shimizu, Kazuyoshi
AU - Taga, Naoyuki
AU - Yamasaki, Masaki
AU - Mori, Hideaki
AU - Fujii, Sonoko
AU - Iwasaki, Tatsuo
N1 - Funding Information:
TK received funding from grants-in-aid for scientific research from the Ministry of Education, Science, and Culture of Japan (MEXT/JSPS KAKENHI grant number JP26861233). This study was supported by grants-in-aid for scientific research from the Ministry of Education, Science, and Culture of Japan (MEXT/JSPSKAKENHI grant number JP26861233).
Publisher Copyright:
© 2022, The Author(s) under exclusive licence to Japanese Society of Anesthesiologists.
PY - 2022/6
Y1 - 2022/6
N2 - Purpose: The purpose of this study is to investigate the current status of postoperative BNP measurement in the pediatric cardiac intensive care unit (PCICU). Methods: This was a prospective multicenter observational study. Children under 15 years old who underwent pediatric cardiac surgery were included. Postoperatively, all BNP measurement was collected in PCICU. We checked whether each BNP measurement was used for the decision-making of intervention or not. We divided the BNP measurements into 4 groups: group A 0–299 pg/ml (reference), group B 300–999 pg/ml, group C 1000–1999 pg/ml, group D ≧ 2000 pg/ml. We performed logistic regression analysis to compare the intervention ratio between group A and B, C, D. We also did multiple comparison analyses to compare the intervention ratio in each group. Results: Thirty-nine (15.8%) measurements were used as a criterion to intervene in all BNP measurements. There was no protocol for the measurement of BNP in all institutions. The number of BNP measurements in each group is as follows: group A 113 (45.9%), group B 81 (32.9%), group C 45 (18.3%), group D 7 (2.8%). The intervention ratio in each group was 6.2% (group A), 8.6% (group B), 44.4% (group C), and 71.4% (group D). The intervention ratio of group C and D were significantly higher than group A: (Odds ratio (95%CI): 12.1(4.8–33.9), p < 0.0001, 25.2(5.2–146.2), p < 0.0001). The result of multiple comparisons is similar to logistic regression analysis. Conclusion: High BNP concentration, especially more than 1000 pg/ml, was more often intervened upon compared to that of less than 1000 pg/ml.
AB - Purpose: The purpose of this study is to investigate the current status of postoperative BNP measurement in the pediatric cardiac intensive care unit (PCICU). Methods: This was a prospective multicenter observational study. Children under 15 years old who underwent pediatric cardiac surgery were included. Postoperatively, all BNP measurement was collected in PCICU. We checked whether each BNP measurement was used for the decision-making of intervention or not. We divided the BNP measurements into 4 groups: group A 0–299 pg/ml (reference), group B 300–999 pg/ml, group C 1000–1999 pg/ml, group D ≧ 2000 pg/ml. We performed logistic regression analysis to compare the intervention ratio between group A and B, C, D. We also did multiple comparison analyses to compare the intervention ratio in each group. Results: Thirty-nine (15.8%) measurements were used as a criterion to intervene in all BNP measurements. There was no protocol for the measurement of BNP in all institutions. The number of BNP measurements in each group is as follows: group A 113 (45.9%), group B 81 (32.9%), group C 45 (18.3%), group D 7 (2.8%). The intervention ratio in each group was 6.2% (group A), 8.6% (group B), 44.4% (group C), and 71.4% (group D). The intervention ratio of group C and D were significantly higher than group A: (Odds ratio (95%CI): 12.1(4.8–33.9), p < 0.0001, 25.2(5.2–146.2), p < 0.0001). The result of multiple comparisons is similar to logistic regression analysis. Conclusion: High BNP concentration, especially more than 1000 pg/ml, was more often intervened upon compared to that of less than 1000 pg/ml.
KW - BNP
KW - Congenital heart disease
KW - Intervention
KW - PCICU
KW - Postoperative management
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U2 - 10.1007/s00540-022-03052-9
DO - 10.1007/s00540-022-03052-9
M3 - Article
C2 - 35274159
AN - SCOPUS:85125999914
VL - 36
SP - 367
EP - 373
JO - Journal of Anesthesia
JF - Journal of Anesthesia
SN - 0913-8668
IS - 3
ER -