The formation of capsule and septum in human hepatocellular carcinoma

Masahiko Ishizaki, Kozo Ashida, Toshihiro Higashi, Harushige Nakatsukasa, Toshihiko Kaneyoshi, Keishi Fujiwara, Kazuhiro Nouso, Yoshiyuki Kobayashi, Masayuki Uemura, Shinichiro Nakamura, Takao Tsuji

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

The formation of fibrous capsule around the cancer nodule and of the septum in the tumor is frequently observed with the development of hepatocellular carcinoma (HCC). We aimed to clarify how the capsule and septum were formed during the growth of HCC. Liver samples surgically resected from 25 patients with HCC were studied with in situ hybridization for type-I, -III, and -IV procollagen. Type-I and -III procollagen-expressing cells, mostly α-smooth muscle actin (SMA)-positive, were increased in the fibrous capsule and in the septum between HCC nodules. These cells were also found at the invasion front of HCC and around the necrotic cancer tissues. Type-IV procollagen gene expression was mainly observed in mesenchymal cells localized in both HCCs and non-cancerous liver. Cancer cells or hepatocytes did not express any of these procollagen genes. The present study reveals that the capsule and septum are mainly formed by α-SMA-positive mesen-chymal cells at the interface between two different tissues (e.g., cancer nodule vs non-cancerous liver or another cancer nodule). The wound healing occurs even in HCC. The capsule formation may result from interaction between tumor and host liver and interfere the growth and invasion of HCC.

Original languageEnglish
Pages (from-to)574-580
Number of pages7
JournalVirchows Archiv
Volume438
Issue number6
DOIs
Publication statusPublished - 2001

Fingerprint

Capsules
Hepatocellular Carcinoma
Neoplasms
Procollagen
Liver
Actins
Collagen Type III
Collagen Type IV
Growth
Wound Healing
Smooth Muscle Myocytes
In Situ Hybridization
Smooth Muscle
Hepatocytes
Gene Expression
Genes

Keywords

  • α-Smooth muscle actin
  • Collagens
  • Hepatocellular carcinoma
  • In situ hybridization
  • Stellate cell

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Ishizaki, M., Ashida, K., Higashi, T., Nakatsukasa, H., Kaneyoshi, T., Fujiwara, K., ... Tsuji, T. (2001). The formation of capsule and septum in human hepatocellular carcinoma. Virchows Archiv, 438(6), 574-580. https://doi.org/10.1007/s004280000391

The formation of capsule and septum in human hepatocellular carcinoma. / Ishizaki, Masahiko; Ashida, Kozo; Higashi, Toshihiro; Nakatsukasa, Harushige; Kaneyoshi, Toshihiko; Fujiwara, Keishi; Nouso, Kazuhiro; Kobayashi, Yoshiyuki; Uemura, Masayuki; Nakamura, Shinichiro; Tsuji, Takao.

In: Virchows Archiv, Vol. 438, No. 6, 2001, p. 574-580.

Research output: Contribution to journalArticle

Ishizaki, M, Ashida, K, Higashi, T, Nakatsukasa, H, Kaneyoshi, T, Fujiwara, K, Nouso, K, Kobayashi, Y, Uemura, M, Nakamura, S & Tsuji, T 2001, 'The formation of capsule and septum in human hepatocellular carcinoma', Virchows Archiv, vol. 438, no. 6, pp. 574-580. https://doi.org/10.1007/s004280000391
Ishizaki M, Ashida K, Higashi T, Nakatsukasa H, Kaneyoshi T, Fujiwara K et al. The formation of capsule and septum in human hepatocellular carcinoma. Virchows Archiv. 2001;438(6):574-580. https://doi.org/10.1007/s004280000391
Ishizaki, Masahiko ; Ashida, Kozo ; Higashi, Toshihiro ; Nakatsukasa, Harushige ; Kaneyoshi, Toshihiko ; Fujiwara, Keishi ; Nouso, Kazuhiro ; Kobayashi, Yoshiyuki ; Uemura, Masayuki ; Nakamura, Shinichiro ; Tsuji, Takao. / The formation of capsule and septum in human hepatocellular carcinoma. In: Virchows Archiv. 2001 ; Vol. 438, No. 6. pp. 574-580.
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