The First Proline of PALP Motif at the C Terminus of Presenilins is Obligatory for Stabilization, Complex Formation, and γ-Secretase Activities of Presenilins

Medicine & Life Sciences

• Presenilins 100%
• Amyloid Precursor Protein Secretases 86%
• Proline 73%
• Leucine 71%
• Alanine 70%
• Alzheimer Disease 12%
• Mutation 8%
• Molecular Weight 8%
• trans-Golgi Network 7%
• Null Lymphocytes 6%
• Proteins 5%
• Caenorhabditis elegans 5%
• Drosophila melanogaster 5%
• Missense Mutation 5%
• Amyloid 5%
• Fibroblasts 3%
• Amino Acids 3%
• Peptides 3%
• Cell Line 3%
• Genes 2%

Chemical Compounds

• Proline 71%
• Mutation 58%
• Protein 21%
• Weight 18%
• Leucine 18%
• Cleavage 11%
• Peptide 10%
• Acid 6%