The first case of non-leukemic sarcoma composed of mixed-phenotype acute leukemia, B/myeloid, not otherwise specified

Teruhito Takakuwa; Takahiko Nakane; Masahiko Ohsawa; Joji Nagasaki; Yasutaka Aoyama; Mistutaka Nishimoto; Yoshiki Hayashi; Yuko Kuwae; Masayuki Hino; Hirohisa Nakamae

doi:10.2169/internalmedicine.9144-17

The first case of non-leukemic sarcoma composed of mixed-phenotype acute leukemia, B/myeloid, not otherwise specified

Teruhito Takakuwa, Takahiko Nakane, Masahiko Ohsawa, Joji Nagasaki, Yasutaka Aoyama, Mistutaka Nishimoto, Yoshiki Hayashi, Yuko Kuwae, Masayuki Hino, Hirohisa Nakamae

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Isolated sarcoma with features of mixed-phenotype acute leukemia (MPAL) is an extremely rare disease and it can be easily misdiagnosed as lymphoma or other malignancies. We herein report the case of a 61-year-old woman with non-leukemic sarcoma of the right pleura, pretracheal lymph node, and supraclavicular lymph node with features of MPAL, B/myeloid, not otherwise specified, which was first misdiagnosed as diffuse large B cell lymphoma. After performing a detailed re-examination of the biopsy specimens, few scattered eosinophilic myelocytes allowed us to reach a correct diagnosis of MPAL and the patient was thereafter successfully treated by intensified chemotherapy followed by cord blood transplantation.

Original language	English
Pages (from-to)	1155-1158
Number of pages	4
Journal	Internal Medicine
Volume	57
Issue number	8
DOIs	https://doi.org/10.2169/internalmedicine.9144-17
Publication status	Published - 2018
Externally published	Yes

Keywords

Chemotherapy
Diagnosis
Mixed-phenotype acute leukemia
Sarcoma
Stem cell transplantation

ASJC Scopus subject areas

Internal Medicine

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10.2169/internalmedicine.9144-17

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title = "The first case of non-leukemic sarcoma composed of mixed-phenotype acute leukemia, B/myeloid, not otherwise specified",

abstract = "Isolated sarcoma with features of mixed-phenotype acute leukemia (MPAL) is an extremely rare disease and it can be easily misdiagnosed as lymphoma or other malignancies. We herein report the case of a 61-year-old woman with non-leukemic sarcoma of the right pleura, pretracheal lymph node, and supraclavicular lymph node with features of MPAL, B/myeloid, not otherwise specified, which was first misdiagnosed as diffuse large B cell lymphoma. After performing a detailed re-examination of the biopsy specimens, few scattered eosinophilic myelocytes allowed us to reach a correct diagnosis of MPAL and the patient was thereafter successfully treated by intensified chemotherapy followed by cord blood transplantation.",

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author = "Teruhito Takakuwa and Takahiko Nakane and Masahiko Ohsawa and Joji Nagasaki and Yasutaka Aoyama and Mistutaka Nishimoto and Yoshiki Hayashi and Yuko Kuwae and Masayuki Hino and Hirohisa Nakamae",

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doi = "10.2169/internalmedicine.9144-17",

language = "English",

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pages = "1155--1158",

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T1 - The first case of non-leukemic sarcoma composed of mixed-phenotype acute leukemia, B/myeloid, not otherwise specified

AU - Takakuwa, Teruhito

AU - Nakane, Takahiko

AU - Ohsawa, Masahiko

AU - Nagasaki, Joji

AU - Aoyama, Yasutaka

AU - Nishimoto, Mistutaka

AU - Hayashi, Yoshiki

AU - Kuwae, Yuko

AU - Hino, Masayuki

AU - Nakamae, Hirohisa

PY - 2018

Y1 - 2018

N2 - Isolated sarcoma with features of mixed-phenotype acute leukemia (MPAL) is an extremely rare disease and it can be easily misdiagnosed as lymphoma or other malignancies. We herein report the case of a 61-year-old woman with non-leukemic sarcoma of the right pleura, pretracheal lymph node, and supraclavicular lymph node with features of MPAL, B/myeloid, not otherwise specified, which was first misdiagnosed as diffuse large B cell lymphoma. After performing a detailed re-examination of the biopsy specimens, few scattered eosinophilic myelocytes allowed us to reach a correct diagnosis of MPAL and the patient was thereafter successfully treated by intensified chemotherapy followed by cord blood transplantation.

AB - Isolated sarcoma with features of mixed-phenotype acute leukemia (MPAL) is an extremely rare disease and it can be easily misdiagnosed as lymphoma or other malignancies. We herein report the case of a 61-year-old woman with non-leukemic sarcoma of the right pleura, pretracheal lymph node, and supraclavicular lymph node with features of MPAL, B/myeloid, not otherwise specified, which was first misdiagnosed as diffuse large B cell lymphoma. After performing a detailed re-examination of the biopsy specimens, few scattered eosinophilic myelocytes allowed us to reach a correct diagnosis of MPAL and the patient was thereafter successfully treated by intensified chemotherapy followed by cord blood transplantation.

KW - Chemotherapy

KW - Diagnosis

KW - Mixed-phenotype acute leukemia

KW - Sarcoma

KW - Stem cell transplantation

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JF - Internal Medicine

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ER -

The first case of non-leukemic sarcoma composed of mixed-phenotype acute leukemia, B/myeloid, not otherwise specified

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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