The Fas antigen and Fas-mediated apoptosis in B-cell differentiation

Tadaatsu Akagi, Tadashi Yoshino, Eisaku Kondo

Research output: Contribution to journalReview article

9 Citations (Scopus)

Abstract

In the B-cell lineage, Fas, a type 1 membrane protein belonging to the tumor necrosis factor receptor (TNF) family, is expressed on B-cells at a restricted developmental stage and on activated B-cells, but not on naive mature B-cells. Apoptosis mediated by Fas-Fas ligand interactions may be involved in the peripheral elimination of autoreactive B-cells and in the regulation of the immune response through deletion of B-cells activated by foreign antigens, as for the T-cell lineage. Fas-mediated apoptosis associated with B-cell activation is affected by costimulation through other accessory signaling molecules like CD40, whose ligands are on T-cells.

Original languageEnglish
Pages (from-to)483-489
Number of pages7
JournalLeukemia and Lymphoma
Volume28
Issue number5-6
DOIs
Publication statusPublished - Jan 1 1998

    Fingerprint

Keywords

  • Apoptosis
  • B-cell differentiation
  • CD95
  • Fas
  • Fas ligand
  • Germinal center

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

Cite this