Abstract
The hippocampal subiculum in the adult rat brain contains many neurons with nerve cell surface glycoproteins which are linked by collagenous ligands to perineuronal proteoglycans. The nerve cell surface glycoproteins or their terminal N-acetylgalactosamines are digested by endo-alpha-N-acetylgalactosaminidase. The terminal N-acetylgalactosamines linked by the collagenous ligands are not digested by endo-alpha-N-acetylgalactosasminidase. The collagenous ligands associated with the terminal N-acetylgalactosamines were digested by collagenase. The newly exposed terminal N-acetylgalactosamines by this collagenase incubation were digested by endo-alpha-N-acetyl-galactosaminidase. These findings on the rat agree with those obtained in our previous studies of the adult mouse brain samples. Furthermore they emphasize our hypothetical model that the perineuronal proteoglycans are related--via collagen ligands--with the nerve cell surface glycoproteins.
| Original language | English |
|---|---|
| Pages (from-to) | 475-480 |
| Number of pages | 6 |
| Journal | Italian journal of anatomy and embryology = Archivio italiano di anatomia ed embriologia |
| Volume | 106 |
| Issue number | 2 Suppl 1 |
| Publication status | Published - 2001 |
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ASJC Scopus subject areas
- Medicine(all)
Cite this
The extracellular matrix in the mature brain : its reactions to endo-alpha-N-acetylgalactosaminidase and collagenase. / Murakami, T.; Murakami, S.; Fuyama, Y.; Taguchi, Takehito; Ohtsuka, Aiji.
In: Italian journal of anatomy and embryology = Archivio italiano di anatomia ed embriologia, Vol. 106, No. 2 Suppl 1, 2001, p. 475-480.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The extracellular matrix in the mature brain
T2 - its reactions to endo-alpha-N-acetylgalactosaminidase and collagenase.
AU - Murakami, T.
AU - Murakami, S.
AU - Fuyama, Y.
AU - Taguchi, Takehito
AU - Ohtsuka, Aiji
PY - 2001
Y1 - 2001
N2 - The hippocampal subiculum in the adult rat brain contains many neurons with nerve cell surface glycoproteins which are linked by collagenous ligands to perineuronal proteoglycans. The nerve cell surface glycoproteins or their terminal N-acetylgalactosamines are digested by endo-alpha-N-acetylgalactosaminidase. The terminal N-acetylgalactosamines linked by the collagenous ligands are not digested by endo-alpha-N-acetylgalactosasminidase. The collagenous ligands associated with the terminal N-acetylgalactosamines were digested by collagenase. The newly exposed terminal N-acetylgalactosamines by this collagenase incubation were digested by endo-alpha-N-acetyl-galactosaminidase. These findings on the rat agree with those obtained in our previous studies of the adult mouse brain samples. Furthermore they emphasize our hypothetical model that the perineuronal proteoglycans are related--via collagen ligands--with the nerve cell surface glycoproteins.
AB - The hippocampal subiculum in the adult rat brain contains many neurons with nerve cell surface glycoproteins which are linked by collagenous ligands to perineuronal proteoglycans. The nerve cell surface glycoproteins or their terminal N-acetylgalactosamines are digested by endo-alpha-N-acetylgalactosaminidase. The terminal N-acetylgalactosamines linked by the collagenous ligands are not digested by endo-alpha-N-acetylgalactosasminidase. The collagenous ligands associated with the terminal N-acetylgalactosamines were digested by collagenase. The newly exposed terminal N-acetylgalactosamines by this collagenase incubation were digested by endo-alpha-N-acetyl-galactosaminidase. These findings on the rat agree with those obtained in our previous studies of the adult mouse brain samples. Furthermore they emphasize our hypothetical model that the perineuronal proteoglycans are related--via collagen ligands--with the nerve cell surface glycoproteins.
UR - http://www.scopus.com/inward/record.url?scp=0035237473&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0035237473&partnerID=8YFLogxK
M3 - Article
C2 - 11729992
AN - SCOPUS:0035237473
VL - 106
SP - 475
EP - 480
JO - Italian Journal of Anatomy and Embryology
JF - Italian Journal of Anatomy and Embryology
SN - 1122-6714
IS - 2 Suppl 1
ER -