THE EXAMINATION OF IGE AND PERIPHERAL BLOOD MONONUCLEAR CELLS RESPONSES TO FLOUR EXTRACTS IN A BAKER'S RHINITIS PATIENT

Takenori Haruna, Mitsuhiro Okano, Tazuko Fujiwara, Takaya Higaki, Shin Kariya, Seiichiro Makihara, Kengo Kanai, Tomoyasu Tachibana, Yuko Matsuyama, Yasutoshi Komatsubara, Yuto Naoi, Kazunori Nishizaki

Research output: Contribution to journalArticle

Abstract

BACKGROUND: Baker's rhinitis is a kind of occupational allergic rhinitis mainly caused by intranasal exposure to wheat and/or rye flour in bakery workers. Continuous exposure to flour may induce the onset of asthma in these patients. METHOD: We experienced a case of 34-year-old male with baker's rhinitis without asthma, and investigated responses of IgE and peripheral blood mononuclear cells (PBMCs) to flour extracts used in the bakery in practice. RESULT: In the immunoblotting, the patient's IgE reacted with 18 and 30kDa molecules in the extracts of 6 flours used in the bakery. The patient's PBMC produced a substantial amount of IL-5 and IL-13 in response to these flour extracts. CONCLUSION: It is suggested that water/salt soluble components of wheat flour selectively induce type 2 cytokines production in baker's rhinitis.

Original languageEnglish
Pages (from-to)35-42
Number of pages8
JournalArerugi = [Allergy]
Volume68
Issue number1
DOIs
Publication statusPublished - Jan 1 2019

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Flour
Rhinitis
Blood Cells
Immunoglobulin E
Triticum
Asthma
Interleukin-13
Interleukin-5
Immunoblotting
Salts
Cytokines
Water

Keywords

  • baker's rhinitis
  • occupational allergic disease
  • occupational rhinitis

ASJC Scopus subject areas

  • Immunology and Allergy

Cite this

THE EXAMINATION OF IGE AND PERIPHERAL BLOOD MONONUCLEAR CELLS RESPONSES TO FLOUR EXTRACTS IN A BAKER'S RHINITIS PATIENT. / Haruna, Takenori; Okano, Mitsuhiro; Fujiwara, Tazuko; Higaki, Takaya; Kariya, Shin; Makihara, Seiichiro; Kanai, Kengo; Tachibana, Tomoyasu; Matsuyama, Yuko; Komatsubara, Yasutoshi; Naoi, Yuto; Nishizaki, Kazunori.

In: Arerugi = [Allergy], Vol. 68, No. 1, 01.01.2019, p. 35-42.

Research output: Contribution to journalArticle

Haruna, T, Okano, M, Fujiwara, T, Higaki, T, Kariya, S, Makihara, S, Kanai, K, Tachibana, T, Matsuyama, Y, Komatsubara, Y, Naoi, Y & Nishizaki, K 2019, 'THE EXAMINATION OF IGE AND PERIPHERAL BLOOD MONONUCLEAR CELLS RESPONSES TO FLOUR EXTRACTS IN A BAKER'S RHINITIS PATIENT', Arerugi = [Allergy], vol. 68, no. 1, pp. 35-42. https://doi.org/10.15036/arerugi.68.35
Haruna, Takenori ; Okano, Mitsuhiro ; Fujiwara, Tazuko ; Higaki, Takaya ; Kariya, Shin ; Makihara, Seiichiro ; Kanai, Kengo ; Tachibana, Tomoyasu ; Matsuyama, Yuko ; Komatsubara, Yasutoshi ; Naoi, Yuto ; Nishizaki, Kazunori. / THE EXAMINATION OF IGE AND PERIPHERAL BLOOD MONONUCLEAR CELLS RESPONSES TO FLOUR EXTRACTS IN A BAKER'S RHINITIS PATIENT. In: Arerugi = [Allergy]. 2019 ; Vol. 68, No. 1. pp. 35-42.
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