The evaluation of bone formation of the whole-tissue periosteum transplantation in combination with β-tricalcium phosphate (TCP)

Takaaki Ueno, Yoshiro Sakata, Azumi Hirata, Toshimasa Kagawa, Miwa Kanou, Nobuaki Shirasu, Masako Sawaki, Kozo Honda, Nobuyoshi Mizukawa, Toshio Sugahara

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

We investigated the osteogenic potential of a combination graft of β-tricalcium phosphate (TCP) and periosteum in the rat calvarial defect model. The combination β-TCP and periosteum graft was grafted into rat calvarial defects; the newly formed bone in the defect was studied histologically and radiographically and compared with periosteum grafts and TCP grafts. Ten days after combination grafting, the grafted periosteum showed cell proliferation and Runx2 immunoreaction; 20 days after grafting, new bone formation was seen around the β-TCP; and 30 days after grafting, new bone developed and actively replaced β-TCP, while radiography showed calcified areas. Total bone formation of the combination periosteum and β-TCP graft was significantly increased compared with single grafts of β-TCP or periosteum (P <0.01). The combination graft of periosteum and β-TCP showed marked bone formation in rat calvarial defects. This result suggests that combination grafts may be effective for repairing bone defects.

Original languageEnglish
Pages (from-to)707-712
Number of pages6
JournalAnnals of Plastic Surgery
Volume59
Issue number6
DOIs
Publication statusPublished - Dec 2007

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Tissue Transplantation
Periosteum
Osteogenesis
Transplants
Bone and Bones
Bone Transplantation
tricalcium phosphate
Radiography
Cell Proliferation

Keywords

  • Osteoconduction
  • Periosteum graft
  • Tricalcium phosphate

ASJC Scopus subject areas

  • Surgery

Cite this

The evaluation of bone formation of the whole-tissue periosteum transplantation in combination with β-tricalcium phosphate (TCP). / Ueno, Takaaki; Sakata, Yoshiro; Hirata, Azumi; Kagawa, Toshimasa; Kanou, Miwa; Shirasu, Nobuaki; Sawaki, Masako; Honda, Kozo; Mizukawa, Nobuyoshi; Sugahara, Toshio.

In: Annals of Plastic Surgery, Vol. 59, No. 6, 12.2007, p. 707-712.

Research output: Contribution to journalArticle

Ueno, Takaaki ; Sakata, Yoshiro ; Hirata, Azumi ; Kagawa, Toshimasa ; Kanou, Miwa ; Shirasu, Nobuaki ; Sawaki, Masako ; Honda, Kozo ; Mizukawa, Nobuyoshi ; Sugahara, Toshio. / The evaluation of bone formation of the whole-tissue periosteum transplantation in combination with β-tricalcium phosphate (TCP). In: Annals of Plastic Surgery. 2007 ; Vol. 59, No. 6. pp. 707-712.
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