We investigated the osteogenic potential of a combination graft of β-tricalcium phosphate (TCP) and periosteum in the rat calvarial defect model. The combination β-TCP and periosteum graft was grafted into rat calvarial defects; the newly formed bone in the defect was studied histologically and radiographically and compared with periosteum grafts and TCP grafts. Ten days after combination grafting, the grafted periosteum showed cell proliferation and Runx2 immunoreaction; 20 days after grafting, new bone formation was seen around the β-TCP; and 30 days after grafting, new bone developed and actively replaced β-TCP, while radiography showed calcified areas. Total bone formation of the combination periosteum and β-TCP graft was significantly increased compared with single grafts of β-TCP or periosteum (P < 0.01). The combination graft of periosteum and β-TCP showed marked bone formation in rat calvarial defects. This result suggests that combination grafts may be effective for repairing bone defects.
|Number of pages||6|
|Journal||Annals of Plastic Surgery|
|Publication status||Published - Dec 1 2007|
- Periosteum graft
- Tricalcium phosphate
ASJC Scopus subject areas