The establishment of a new mouse model with orthotopic esophageal cancer showing the esophageal stricture

Toshiaki Ohara, Munenori Takaoka, Kazufumi Sakurama, Kaori Nagaishi, Haruo Takeda, Yasuhiro Shirakawa, Tomoki Yamatsuji, Takeshi Nagasaka, Junji Matsuoka, Noriaki Tanaka, Yoshio Naomoto

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16 Citations (Scopus)

Abstract

We established a promising new experimental animal model with an orthotopic xenograft of esophageal cancer that successfully represents poor oral intake, a major clinical feature of esophageal cancer. The advantage of this model is that no surgical technique is required, only the injection of a cell suspension by a needle and syringe via the esophageal lumen from the mouth, which provides a high reproducibility of tumor implantation and a rapid progress of outcome. We propose that this model is useful to study cancer-related outcomes and for developing new therapies for esophageal cancer, and we expect it to make a contribution to clinical practice.

Original languageEnglish
Pages (from-to)207-212
Number of pages6
JournalCancer Letters
Volume293
Issue number2
DOIs
Publication statusPublished - Jul 1 2010

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Keywords

  • Animal model
  • Esophageal cancer
  • Orthotopic xenograft
  • Prognosis

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Ohara, T., Takaoka, M., Sakurama, K., Nagaishi, K., Takeda, H., Shirakawa, Y., Yamatsuji, T., Nagasaka, T., Matsuoka, J., Tanaka, N., & Naomoto, Y. (2010). The establishment of a new mouse model with orthotopic esophageal cancer showing the esophageal stricture. Cancer Letters, 293(2), 207-212. https://doi.org/10.1016/j.canlet.2010.01.017