Abstract
To investigate whether bone marrow-derived cells (BMC) would migrate and engraft into the sensory epithelium of the inner ear, BMC of green fluorescence protein (GFP) mice were transplanted into lethally irradiated recipient mice. Then the recipient mice were treated with streptomycin and immunohistochemical staining was performed to evaluate the migration and engraftment of donor BMC into the sensory epithelium of the inner ear. Immunohistochemical staining for GFP was found initially in the vascular epithelium and oral mucosa but not in the sensory epithelium of the inner ear. In the case of mouse, BMC may not migrate and be engrafted into the sensory epithelium of the inner ear.
| Original language | English |
|---|---|
| Pages (from-to) | 59-63 |
| Number of pages | 5 |
| Journal | European Archives of Oto-Rhino-Laryngology |
| Volume | 266 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jan 2009 |
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Keywords
- Bone marrow
- Engraftment
- GFP mice
- Inner ear
- Transplantation
ASJC Scopus subject areas
- Otorhinolaryngology
Cite this
The engraftment of transplanted bone marrow-derived cells into the inner ear. / Orita, Yorihisa; Tsujigiwa, Hidetsugu; Nishizaki, Kazunori; Teshima, Takanori; Yoshinobu, Junko; Orita, Saeko; Takeuchi, Ayako; Takeda, Yasushi; Nagatsuka, Hitoshi; Nagai, Noriyuki.
In: European Archives of Oto-Rhino-Laryngology, Vol. 266, No. 1, 01.2009, p. 59-63.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The engraftment of transplanted bone marrow-derived cells into the inner ear
AU - Orita, Yorihisa
AU - Tsujigiwa, Hidetsugu
AU - Nishizaki, Kazunori
AU - Teshima, Takanori
AU - Yoshinobu, Junko
AU - Orita, Saeko
AU - Takeuchi, Ayako
AU - Takeda, Yasushi
AU - Nagatsuka, Hitoshi
AU - Nagai, Noriyuki
PY - 2009/1
Y1 - 2009/1
N2 - To investigate whether bone marrow-derived cells (BMC) would migrate and engraft into the sensory epithelium of the inner ear, BMC of green fluorescence protein (GFP) mice were transplanted into lethally irradiated recipient mice. Then the recipient mice were treated with streptomycin and immunohistochemical staining was performed to evaluate the migration and engraftment of donor BMC into the sensory epithelium of the inner ear. Immunohistochemical staining for GFP was found initially in the vascular epithelium and oral mucosa but not in the sensory epithelium of the inner ear. In the case of mouse, BMC may not migrate and be engrafted into the sensory epithelium of the inner ear.
AB - To investigate whether bone marrow-derived cells (BMC) would migrate and engraft into the sensory epithelium of the inner ear, BMC of green fluorescence protein (GFP) mice were transplanted into lethally irradiated recipient mice. Then the recipient mice were treated with streptomycin and immunohistochemical staining was performed to evaluate the migration and engraftment of donor BMC into the sensory epithelium of the inner ear. Immunohistochemical staining for GFP was found initially in the vascular epithelium and oral mucosa but not in the sensory epithelium of the inner ear. In the case of mouse, BMC may not migrate and be engrafted into the sensory epithelium of the inner ear.
KW - Bone marrow
KW - Engraftment
KW - GFP mice
KW - Inner ear
KW - Transplantation
UR - http://www.scopus.com/inward/record.url?scp=57149134722&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=57149134722&partnerID=8YFLogxK
U2 - 10.1007/s00405-008-0725-6
DO - 10.1007/s00405-008-0725-6
M3 - Article
C2 - 18542978
AN - SCOPUS:57149134722
VL - 266
SP - 59
EP - 63
JO - European Archives of Oto-Rhino-Laryngology
JF - European Archives of Oto-Rhino-Laryngology
SN - 0937-4477
IS - 1
ER -