The engraftment of transplanted bone marrow-derived cells into the inner ear

Yorihisa Orita; Hidetsugu Tsujigiwa; Kazunori Nishizaki; Takanori Teshima; Junko Yoshinobu; Saeko Orita; Ayako Takeuchi; Yasushi Takeda; Hitoshi Nagatsuka; Noriyuki Nagai

doi:10.1007/s00405-008-0725-6

The engraftment of transplanted bone marrow-derived cells into the inner ear

Yorihisa Orita, Hidetsugu Tsujigiwa, Kazunori Nishizaki, Takanori Teshima, Junko Yoshinobu, Saeko Orita, Ayako Takeuchi, Yasushi Takeda, Hitoshi Nagatsuka, Noriyuki Nagai

Research output: Contribution to journal › Article › peer-review

Abstract

To investigate whether bone marrow-derived cells (BMC) would migrate and engraft into the sensory epithelium of the inner ear, BMC of green fluorescence protein (GFP) mice were transplanted into lethally irradiated recipient mice. Then the recipient mice were treated with streptomycin and immunohistochemical staining was performed to evaluate the migration and engraftment of donor BMC into the sensory epithelium of the inner ear. Immunohistochemical staining for GFP was found initially in the vascular epithelium and oral mucosa but not in the sensory epithelium of the inner ear. In the case of mouse, BMC may not migrate and be engrafted into the sensory epithelium of the inner ear.

Original language	English
Pages (from-to)	59-63
Number of pages	5
Journal	European Archives of Oto-Rhino-Laryngology
Volume	266
Issue number	1
DOIs	https://doi.org/10.1007/s00405-008-0725-6
Publication status	Published - Jan 2009

Keywords

Bone marrow
Engraftment
GFP mice
Inner ear
Transplantation

ASJC Scopus subject areas

Otorhinolaryngology

Access to Document

10.1007/s00405-008-0725-6

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The engraftment of transplanted bone marrow-derived cells into the inner ear. / Orita, Yorihisa; Tsujigiwa, Hidetsugu; Nishizaki, Kazunori; Teshima, Takanori; Yoshinobu, Junko; Orita, Saeko; Takeuchi, Ayako; Takeda, Yasushi; Nagatsuka, Hitoshi; Nagai, Noriyuki.

In: European Archives of Oto-Rhino-Laryngology, Vol. 266, No. 1, 01.2009, p. 59-63.

Research output: Contribution to journal › Article › peer-review

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AU - Orita, Saeko

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