The engraftment of transplanted bone marrow-derived cells into the inner ear

Yorihisa Orita, Hidetsugu Tsujigiwa, Kazunori Nishizaki, Takanori Teshima, Junko Yoshinobu, Saeko Orita, Ayako Takeuchi, Yasushi Takeda, Hitoshi Nagatsuka, Noriyuki Nagai

Research output: Contribution to journalArticle

Abstract

To investigate whether bone marrow-derived cells (BMC) would migrate and engraft into the sensory epithelium of the inner ear, BMC of green fluorescence protein (GFP) mice were transplanted into lethally irradiated recipient mice. Then the recipient mice were treated with streptomycin and immunohistochemical staining was performed to evaluate the migration and engraftment of donor BMC into the sensory epithelium of the inner ear. Immunohistochemical staining for GFP was found initially in the vascular epithelium and oral mucosa but not in the sensory epithelium of the inner ear. In the case of mouse, BMC may not migrate and be engrafted into the sensory epithelium of the inner ear.

Original languageEnglish
Pages (from-to)59-63
Number of pages5
JournalEuropean Archives of Oto-Rhino-Laryngology
Volume266
Issue number1
DOIs
Publication statusPublished - Jan 2009

Keywords

  • Bone marrow
  • Engraftment
  • GFP mice
  • Inner ear
  • Transplantation

ASJC Scopus subject areas

  • Otorhinolaryngology

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  • Cite this

    Orita, Y., Tsujigiwa, H., Nishizaki, K., Teshima, T., Yoshinobu, J., Orita, S., Takeuchi, A., Takeda, Y., Nagatsuka, H., & Nagai, N. (2009). The engraftment of transplanted bone marrow-derived cells into the inner ear. European Archives of Oto-Rhino-Laryngology, 266(1), 59-63. https://doi.org/10.1007/s00405-008-0725-6