The efficacy of rituximab in high-risk renal transplant recipients

Motoo Araki, Koichiro Wada, Yosuke Mitsui, Risa Kubota, Takashi Yoshioka, Yuichi Ariyoshi, Yasuyuki Kobayashi, Masashi Kitagawa, Katsuyuki Tanabe, Hiroshi Sugiyama, Jun Wada, Masami Watanabe, Toyohiko Watanabe, Katsuyuki Hotta, Yasutomo Nasu

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Although graft survival following renal transplantation (RTx) has improved, outcomes following highrisk RTx are variable. Preexisting antibodies, including donor-specific antibodies (DSA), play an important role in graft dysfunction and survival. We have designed a study to investigate the safety and efficacy of anti-CD20 monoclonal antibodies (rituximab) in high-risk RTx recipients. Major eligibility criteria include: 1) major and minor ABO blood group mismatch, 2) positive DSA. Thirty-five patients will receive 200 mg/body of rituximab. The primary endpoint is the incidence of B cell depletion. This study will clarify whether rituximab is efficacious in improving graft survival in high-risk RTx recipients.

Original languageEnglish
Pages (from-to)295-298
Number of pages4
JournalActa medica Okayama
Volume70
Issue number4
Publication statusPublished - 2016

Keywords

  • End-stage renal disease
  • Immunosuppression
  • Kidney transplantation

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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