Abstract
Purpose: To evaluate the efficacy of radiotherapy for portal tumor emboli of hepatocellular carcinoma. Materials and Methods: Twenty-four patients with portal tumor emboli of hepatocellular carcinoma who were treated with radiotherapy from August 1995 to December 1999 were retrospectively studied. Patients were classified according to the degree of portal tumor emboli (Vp2: 3. Vp3: 14. Vp4: 7) and liver damage (A: 8, B: 11, C: 4. unknown: 1). The responses were classified as effective, no change, or progression. The liver function between pre- and post-radiotherapy was compared. Results: The responses were effective for 12 cases (75%) and no change for 4 cases (25%). Cause specific survival rate at 1 year and 50% survival time was 24.4% and 6.3 months, respectively. Cause specific survival rate at 1 year for liver damage A and Vp3 were 60% and 38% respectively. 50% survival time for liver damage A and Vp3 were 11 months and 11.3 months respectively. Prolongation of the prognosis over 6 months was observed in a few cases of liver damage B. Liver function with local irradiation was generally tolerable. Conclusions: Radiotherapy for portal tumor emboli of hepatocellular carcinoma was useful as one of multimodality treatments for advanced hepatocellular carcinoma. This treatment sometimes expected prolongation of the prognosis for hepatocellular carcinoma with portal tumor emboli.
| Original language | English |
|---|---|
| Pages (from-to) | 33-38 |
| Number of pages | 6 |
| Journal | Journal of JASTRO |
| Volume | 14 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2002 |
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Keywords
- Hepatocellular carcinoma
- Portal tumor emboli
- Radiotherapy
ASJC Scopus subject areas
- Oncology
- Radiology Nuclear Medicine and imaging
Cite this
The efficacy of radiotherapy in association with multidisciplinary treatment for portal tumor emboli of hepatocellular carcinoma. / Himei, Kengo; Yamamoto, Michinori; Katsui, Kuniaki; Yoshida, Atsushi; Takemoto, Mitsuhiro; Kobayashi, Mitsuru; Kuroda, Masahiro; Sakae, Katsuyoshi; Kanazawa, Susumu; Hiraki, Yoshio.
In: Journal of JASTRO, Vol. 14, No. 1, 2002, p. 33-38.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The efficacy of radiotherapy in association with multidisciplinary treatment for portal tumor emboli of hepatocellular carcinoma
AU - Himei, Kengo
AU - Yamamoto, Michinori
AU - Katsui, Kuniaki
AU - Yoshida, Atsushi
AU - Takemoto, Mitsuhiro
AU - Kobayashi, Mitsuru
AU - Kuroda, Masahiro
AU - Sakae, Katsuyoshi
AU - Kanazawa, Susumu
AU - Hiraki, Yoshio
PY - 2002
Y1 - 2002
N2 - Purpose: To evaluate the efficacy of radiotherapy for portal tumor emboli of hepatocellular carcinoma. Materials and Methods: Twenty-four patients with portal tumor emboli of hepatocellular carcinoma who were treated with radiotherapy from August 1995 to December 1999 were retrospectively studied. Patients were classified according to the degree of portal tumor emboli (Vp2: 3. Vp3: 14. Vp4: 7) and liver damage (A: 8, B: 11, C: 4. unknown: 1). The responses were classified as effective, no change, or progression. The liver function between pre- and post-radiotherapy was compared. Results: The responses were effective for 12 cases (75%) and no change for 4 cases (25%). Cause specific survival rate at 1 year and 50% survival time was 24.4% and 6.3 months, respectively. Cause specific survival rate at 1 year for liver damage A and Vp3 were 60% and 38% respectively. 50% survival time for liver damage A and Vp3 were 11 months and 11.3 months respectively. Prolongation of the prognosis over 6 months was observed in a few cases of liver damage B. Liver function with local irradiation was generally tolerable. Conclusions: Radiotherapy for portal tumor emboli of hepatocellular carcinoma was useful as one of multimodality treatments for advanced hepatocellular carcinoma. This treatment sometimes expected prolongation of the prognosis for hepatocellular carcinoma with portal tumor emboli.
AB - Purpose: To evaluate the efficacy of radiotherapy for portal tumor emboli of hepatocellular carcinoma. Materials and Methods: Twenty-four patients with portal tumor emboli of hepatocellular carcinoma who were treated with radiotherapy from August 1995 to December 1999 were retrospectively studied. Patients were classified according to the degree of portal tumor emboli (Vp2: 3. Vp3: 14. Vp4: 7) and liver damage (A: 8, B: 11, C: 4. unknown: 1). The responses were classified as effective, no change, or progression. The liver function between pre- and post-radiotherapy was compared. Results: The responses were effective for 12 cases (75%) and no change for 4 cases (25%). Cause specific survival rate at 1 year and 50% survival time was 24.4% and 6.3 months, respectively. Cause specific survival rate at 1 year for liver damage A and Vp3 were 60% and 38% respectively. 50% survival time for liver damage A and Vp3 were 11 months and 11.3 months respectively. Prolongation of the prognosis over 6 months was observed in a few cases of liver damage B. Liver function with local irradiation was generally tolerable. Conclusions: Radiotherapy for portal tumor emboli of hepatocellular carcinoma was useful as one of multimodality treatments for advanced hepatocellular carcinoma. This treatment sometimes expected prolongation of the prognosis for hepatocellular carcinoma with portal tumor emboli.
KW - Hepatocellular carcinoma
KW - Portal tumor emboli
KW - Radiotherapy
UR - http://www.scopus.com/inward/record.url?scp=85024712734&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85024712734&partnerID=8YFLogxK
U2 - 10.11182/jastro1989.14.33
DO - 10.11182/jastro1989.14.33
M3 - Article
VL - 14
SP - 33
EP - 38
JO - Journal of JASTRO
JF - Journal of JASTRO
SN - 1040-9564
IS - 1
ER -