TY - JOUR
T1 - The efficacy of OK-432 sclerotherapy on thyroglossal duct cyst and the influence on a subsequent surgical procedure
AU - Tachibana, Tomoyasu
AU - Kariya, Shin
AU - Orita, Yorihisa
AU - Makino, Takuma
AU - Haruna, Takenori
AU - Matsuyama, Yuko
AU - Komatsubara, Yasutoshi
AU - Naoi, Yuto
AU - Nakada, Michihiro
AU - Wani, Yoji
AU - Fushimi, Soichiro
AU - Hotta, Machiko
AU - Haruna, Katsuya
AU - Nagatani, Tami
AU - Sato, Yasuharu
AU - Nishizaki, Kazunori
N1 - Publisher Copyright:
© 2019, © 2019 Acta Oto-Laryngologica AB (Ltd).
PY - 2019/9/2
Y1 - 2019/9/2
N2 - Background: Although there are studies regarding the efficacy of OK-432 sclerotherapy on thyroglossal duct cyst (TDC), its effects on surgical procedure following this therapy have not been properly described. Objectives: The present study aimed to delineate the prognostic factors of OK-432 sclerotherapy in patients with TDC and investigate its influence on subsequent surgical procedure and the histological characteristics in patients with poor response to OK-432 sclerotherapy. Material and methods: We conducted a retrospective analysis of the medical records of 20 TDC patients treated with OK-432 sclerotherapy. Results: Of the 20 patients, OK-432 sclerotherapy was effective in 5 patients (25.0%). OK-432 showed a lower effective rate in multilocular cysts (9.1%) than in unilocular cysts (44.4%), although not significantly. Five cases were treated with surgery following OK-432 sclerotherapy. There was no significant difference in the operating time and the amount of bleeding between patients with and without OK-432 sclerotherapy. From the results of the histological examination of the cyst wall, two cases had stratified squamous epithelium and two cases showed the absence of lymphocyte infiltration. Conclusion and significance: OK-432 sclerotherapy is an acceptable initial treatment for TDC, especially in unilocular cysts, because of lack of influence on surgical procedure.
AB - Background: Although there are studies regarding the efficacy of OK-432 sclerotherapy on thyroglossal duct cyst (TDC), its effects on surgical procedure following this therapy have not been properly described. Objectives: The present study aimed to delineate the prognostic factors of OK-432 sclerotherapy in patients with TDC and investigate its influence on subsequent surgical procedure and the histological characteristics in patients with poor response to OK-432 sclerotherapy. Material and methods: We conducted a retrospective analysis of the medical records of 20 TDC patients treated with OK-432 sclerotherapy. Results: Of the 20 patients, OK-432 sclerotherapy was effective in 5 patients (25.0%). OK-432 showed a lower effective rate in multilocular cysts (9.1%) than in unilocular cysts (44.4%), although not significantly. Five cases were treated with surgery following OK-432 sclerotherapy. There was no significant difference in the operating time and the amount of bleeding between patients with and without OK-432 sclerotherapy. From the results of the histological examination of the cyst wall, two cases had stratified squamous epithelium and two cases showed the absence of lymphocyte infiltration. Conclusion and significance: OK-432 sclerotherapy is an acceptable initial treatment for TDC, especially in unilocular cysts, because of lack of influence on surgical procedure.
KW - OK432 sclerotherapy
KW - surgical results
KW - thyroglossal duct cyst
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U2 - 10.1080/00016489.2019.1633019
DO - 10.1080/00016489.2019.1633019
M3 - Article
C2 - 31271329
AN - SCOPUS:85068548758
SN - 0001-6489
VL - 139
SP - 788
EP - 792
JO - Acta Oto-Laryngologica
JF - Acta Oto-Laryngologica
IS - 9
ER -