The efficacy of OK-432 sclerotherapy on thyroglossal duct cyst and the influence on a subsequent surgical procedure

Tomoyasu Tachibana, Shin Kariya, Yorihisa Orita, Takuma Makino, Takenori Haruna, Yuko Matsuyama, Yasutoshi Komatsubara, Yuto Naoi, Michihiro Nakada, Yoji Wani, Soichiro Fushimi, Machiko Hotta, Katsuya Haruna, Tami Nagatani, Yasuharu Sato, Kazunori Nishizaki

Research output: Contribution to journalArticle

Abstract

Background: Although there are studies regarding the efficacy of OK-432 sclerotherapy on thyroglossal duct cyst (TDC), its effects on surgical procedure following this therapy have not been properly described. Objectives: The present study aimed to delineate the prognostic factors of OK-432 sclerotherapy in patients with TDC and investigate its influence on subsequent surgical procedure and the histological characteristics in patients with poor response to OK-432 sclerotherapy. Material and methods: We conducted a retrospective analysis of the medical records of 20 TDC patients treated with OK-432 sclerotherapy. Results: Of the 20 patients, OK-432 sclerotherapy was effective in 5 patients (25.0%). OK-432 showed a lower effective rate in multilocular cysts (9.1%) than in unilocular cysts (44.4%), although not significantly. Five cases were treated with surgery following OK-432 sclerotherapy. There was no significant difference in the operating time and the amount of bleeding between patients with and without OK-432 sclerotherapy. From the results of the histological examination of the cyst wall, two cases had stratified squamous epithelium and two cases showed the absence of lymphocyte infiltration. Conclusion and significance: OK-432 sclerotherapy is an acceptable initial treatment for TDC, especially in unilocular cysts, because of lack of influence on surgical procedure.

Original languageEnglish
JournalActa Oto-Laryngologica
DOIs
Publication statusPublished - Jan 1 2019

Fingerprint

Thyroglossal Cyst
Picibanil
Sclerotherapy
Cysts
Bleeding Time
Medical Records
Epithelium
Lymphocytes

Keywords

  • OK432 sclerotherapy
  • surgical results
  • thyroglossal duct cyst

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

The efficacy of OK-432 sclerotherapy on thyroglossal duct cyst and the influence on a subsequent surgical procedure. / Tachibana, Tomoyasu; Kariya, Shin; Orita, Yorihisa; Makino, Takuma; Haruna, Takenori; Matsuyama, Yuko; Komatsubara, Yasutoshi; Naoi, Yuto; Nakada, Michihiro; Wani, Yoji; Fushimi, Soichiro; Hotta, Machiko; Haruna, Katsuya; Nagatani, Tami; Sato, Yasuharu; Nishizaki, Kazunori.

In: Acta Oto-Laryngologica, 01.01.2019.

Research output: Contribution to journalArticle

Tachibana, Tomoyasu ; Kariya, Shin ; Orita, Yorihisa ; Makino, Takuma ; Haruna, Takenori ; Matsuyama, Yuko ; Komatsubara, Yasutoshi ; Naoi, Yuto ; Nakada, Michihiro ; Wani, Yoji ; Fushimi, Soichiro ; Hotta, Machiko ; Haruna, Katsuya ; Nagatani, Tami ; Sato, Yasuharu ; Nishizaki, Kazunori. / The efficacy of OK-432 sclerotherapy on thyroglossal duct cyst and the influence on a subsequent surgical procedure. In: Acta Oto-Laryngologica. 2019.
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abstract = "Background: Although there are studies regarding the efficacy of OK-432 sclerotherapy on thyroglossal duct cyst (TDC), its effects on surgical procedure following this therapy have not been properly described. Objectives: The present study aimed to delineate the prognostic factors of OK-432 sclerotherapy in patients with TDC and investigate its influence on subsequent surgical procedure and the histological characteristics in patients with poor response to OK-432 sclerotherapy. Material and methods: We conducted a retrospective analysis of the medical records of 20 TDC patients treated with OK-432 sclerotherapy. Results: Of the 20 patients, OK-432 sclerotherapy was effective in 5 patients (25.0{\%}). OK-432 showed a lower effective rate in multilocular cysts (9.1{\%}) than in unilocular cysts (44.4{\%}), although not significantly. Five cases were treated with surgery following OK-432 sclerotherapy. There was no significant difference in the operating time and the amount of bleeding between patients with and without OK-432 sclerotherapy. From the results of the histological examination of the cyst wall, two cases had stratified squamous epithelium and two cases showed the absence of lymphocyte infiltration. Conclusion and significance: OK-432 sclerotherapy is an acceptable initial treatment for TDC, especially in unilocular cysts, because of lack of influence on surgical procedure.",
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AU - Tachibana, Tomoyasu

AU - Kariya, Shin

AU - Orita, Yorihisa

AU - Makino, Takuma

AU - Haruna, Takenori

AU - Matsuyama, Yuko

AU - Komatsubara, Yasutoshi

AU - Naoi, Yuto

AU - Nakada, Michihiro

AU - Wani, Yoji

AU - Fushimi, Soichiro

AU - Hotta, Machiko

AU - Haruna, Katsuya

AU - Nagatani, Tami

AU - Sato, Yasuharu

AU - Nishizaki, Kazunori

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N2 - Background: Although there are studies regarding the efficacy of OK-432 sclerotherapy on thyroglossal duct cyst (TDC), its effects on surgical procedure following this therapy have not been properly described. Objectives: The present study aimed to delineate the prognostic factors of OK-432 sclerotherapy in patients with TDC and investigate its influence on subsequent surgical procedure and the histological characteristics in patients with poor response to OK-432 sclerotherapy. Material and methods: We conducted a retrospective analysis of the medical records of 20 TDC patients treated with OK-432 sclerotherapy. Results: Of the 20 patients, OK-432 sclerotherapy was effective in 5 patients (25.0%). OK-432 showed a lower effective rate in multilocular cysts (9.1%) than in unilocular cysts (44.4%), although not significantly. Five cases were treated with surgery following OK-432 sclerotherapy. There was no significant difference in the operating time and the amount of bleeding between patients with and without OK-432 sclerotherapy. From the results of the histological examination of the cyst wall, two cases had stratified squamous epithelium and two cases showed the absence of lymphocyte infiltration. Conclusion and significance: OK-432 sclerotherapy is an acceptable initial treatment for TDC, especially in unilocular cysts, because of lack of influence on surgical procedure.

AB - Background: Although there are studies regarding the efficacy of OK-432 sclerotherapy on thyroglossal duct cyst (TDC), its effects on surgical procedure following this therapy have not been properly described. Objectives: The present study aimed to delineate the prognostic factors of OK-432 sclerotherapy in patients with TDC and investigate its influence on subsequent surgical procedure and the histological characteristics in patients with poor response to OK-432 sclerotherapy. Material and methods: We conducted a retrospective analysis of the medical records of 20 TDC patients treated with OK-432 sclerotherapy. Results: Of the 20 patients, OK-432 sclerotherapy was effective in 5 patients (25.0%). OK-432 showed a lower effective rate in multilocular cysts (9.1%) than in unilocular cysts (44.4%), although not significantly. Five cases were treated with surgery following OK-432 sclerotherapy. There was no significant difference in the operating time and the amount of bleeding between patients with and without OK-432 sclerotherapy. From the results of the histological examination of the cyst wall, two cases had stratified squamous epithelium and two cases showed the absence of lymphocyte infiltration. Conclusion and significance: OK-432 sclerotherapy is an acceptable initial treatment for TDC, especially in unilocular cysts, because of lack of influence on surgical procedure.

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