The Efficacy and Safety of Steroids for Preventing Postembolization Syndrome after Transcatheter Arterial Chemoembolization of Hepatocellular Carcinoma

Kenji Kuwaki, Kazuhiro Nouso, Manabi Miyashita, Yasuhiro Makino, Hiroaki Hagihara, Akio Moriya, Takuya Adachi, Nozomu Wada, Yuki Yasunaka, Tetsuya Yasunaka, Yasuto Takeuchi, Hideki Ohnishi, Shinichiro Nakamura, Fusao Ikeda, Hidenori Shiraha, Akinobu Takaki, Hiroyuki Okada

Research output: Contribution to journalArticle


Steroids are often administered at the time of transcatheter arterial chemoembolization (TACE), a standard treatment of hepatocellular carcinoma (HCC), with the expectation of preventing postembolization syndrome. Here we investigated the precise effects of steroids on TACE. We prospectively enrolled 144 HCC patients from 10 hospitals who underwent TACE. Three hospitals used steroids (steroid group, n=77) and the rest did not routinely use steroids (control group, n=67). The occurrence of adverse events and the algetic degree at 1-5 days post-treatment were compared between the groups. Fever (grades 0-2) after TACE was significantly less in the steroid group (56/21/0) compared to the control group (35/29/3, p=0.005, Cochran-Armitage test for trend). The suppressive effect of steroids against fever was prominent in females (p=0.001). Vomiting (G0/G1/ G2-) was also less frequent in the steroid group (70/5/2) versus the control group (53/10/3), but not significantly (p=0.106). The algetic degree and the grade of hematological adverse events, including hyperglycemia, did not differ between the groups. We conclude that the administration of steroids was useful for the prevention of adverse events after TACE in patients with HCC.

Original languageEnglish
Pages (from-to)333-339
Number of pages7
JournalActa medica Okayama
Issue number4
Publication statusPublished - Aug 1 2019



  • antipyretic
  • hepatocellular carcinoma
  • steroid
  • therapeutic chemoembolization

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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