The effects of streptozotocin-induced hypoinsulinemia on serum lipid levels in spontaneously hyperlipidemic rats

Hironori Nakura, M. Tanaka, T. Tateishi, M. Watanabe, T. Kumai, S. Kobayashi

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

We compared the effects of streptozotocin (STZ) treatment on serum cholesterol and lipoprotein levels in spontaneously hyperlipidemic rats (HLR), a hereditary hyperlipidemic model animal, with those in Sprague-Dawley rats (SDR). The body weight of control SDR and HLR were increased continuously for 30 days. Both SDR and HLR lost their body weight after STZ administration. Glucose levels of SDR and HLR were significantly increased by STZ treatment. Insulin levels were markedly decreased in HLR compared with those in SDR. Serum cholesterol and triglyceride levels of HLR treated with STZ were significantly higher than those of untreated HLR. The increment of both levels in HLR was much larger than that in SDR. The high density lipoprotein (HDL) cholesterol level of the STZ-treated HLR was significantly lower than that of untreated HLR. In the STZ-treated HLR the intensities of both bands of the very low density lipoprotein (VLDL) and the low density lipoprotein (LDL) were higher than those in untreated HLR, while the intensity of any lipoprotein band remained unchanged between SZT-treated and control SDR. The atherogenic index (the ratio of total cholesterol level minus HDL cholesterol level to HDL cholesterol level) in the STZ-treated HLR was significantly high compared with that in other groups. The STZ-treated HLR showed the extremely hyperlipidemic state and this animal might be useful in experiments for the development of atherosclerosis or the drug evaluation for the agents used in hyperlipidemia.

Original languageEnglish
Pages (from-to)454-457
Number of pages4
JournalHormone and Metabolic Research
Volume29
Issue number9
Publication statusPublished - 1997
Externally publishedYes

Fingerprint

Streptozocin
Rats
Lipids
Serum
Sprague Dawley Rats
HDL Cholesterol
Cholesterol
Body Weight
Drug Evaluation
VLDL Lipoproteins
Animals
Hyperlipidemias
LDL Lipoproteins
Lipoproteins
Atherosclerosis
Triglycerides
Animal Models

Keywords

  • Atherogenic index
  • Cholesterol
  • HDL
  • Hyperglycemia
  • Hyperlipidemia
  • LDL
  • Lipoprotein
  • Streptozotocin

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology

Cite this

The effects of streptozotocin-induced hypoinsulinemia on serum lipid levels in spontaneously hyperlipidemic rats. / Nakura, Hironori; Tanaka, M.; Tateishi, T.; Watanabe, M.; Kumai, T.; Kobayashi, S.

In: Hormone and Metabolic Research, Vol. 29, No. 9, 1997, p. 454-457.

Research output: Contribution to journalArticle

Nakura, H, Tanaka, M, Tateishi, T, Watanabe, M, Kumai, T & Kobayashi, S 1997, 'The effects of streptozotocin-induced hypoinsulinemia on serum lipid levels in spontaneously hyperlipidemic rats', Hormone and Metabolic Research, vol. 29, no. 9, pp. 454-457.
Nakura, Hironori ; Tanaka, M. ; Tateishi, T. ; Watanabe, M. ; Kumai, T. ; Kobayashi, S. / The effects of streptozotocin-induced hypoinsulinemia on serum lipid levels in spontaneously hyperlipidemic rats. In: Hormone and Metabolic Research. 1997 ; Vol. 29, No. 9. pp. 454-457.
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