Abstract
The effects of highly selective antagonists to μ-, δ-, and κ-opioid receptor subtypes on hyperosmotic- or angiotensin II (AII)-induced arginine vasotocin (AVT) release were investigated in chicks. Plasma levels of AVT increased about 1.5-fold after the administration of 1.5 M NaCl (200 μl, ip) or 100 ng AII (5 μl, icv). The administration of the μ-antagonist naloxonazine and the κ-antagonist nor-Binaltorphimine further elevated plasma levels of AVT stimulated by hypertonic NaCl or AII. These effects of μ- and κ-opioid receptor antagonists on AVT release were dose dependent. Nor-Binahorphimine enhanced hyperosmotically stimulated plasma levels of AVT at a lower dose than that of naloxonazine. Conversely, the δ-selective antagonist naltrindole did not significantly affect AVT secretion. None of the opioid receptor antagonists influenced basal plasma levels of AVT. Therefore, these results suggest that μ- and δ-opioid receptors are involved in hyperosmotic- and AII-induced AVT release, and the effect of the κ-opioid receptor antagonist in the AVT release stimulated by hyperosmolality is strong compared to that of the μ-opioid receptor antagonist, (C) 2000 Academic Press.
| Original language | English |
|---|---|
| Pages (from-to) | 365-372 |
| Number of pages | 8 |
| Journal | General and Comparative Endocrinology |
| Volume | 118 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Jun 2000 |
| Externally published | Yes |
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Keywords
- Angiotensin II
- Arginine vasotocin
- Chicks
- Hypertonic stimulation
- Naloxonazine
- Naltrindole
- Nor-BNI
- Opioid receptor
ASJC Scopus subject areas
- Endocrinology
Cite this
The effects of highly selective opioid receptor antagonists on the release of arginine vasotocin induced by hyperosmotic stimulation and angiotensin II injection. / Sasaki, Takeshi; Arakawa, Koji; Shimada, Kiyoshi; Saito, Noboru.
In: General and Comparative Endocrinology, Vol. 118, No. 3, 06.2000, p. 365-372.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The effects of highly selective opioid receptor antagonists on the release of arginine vasotocin induced by hyperosmotic stimulation and angiotensin II injection
AU - Sasaki, Takeshi
AU - Arakawa, Koji
AU - Shimada, Kiyoshi
AU - Saito, Noboru
PY - 2000/6
Y1 - 2000/6
N2 - The effects of highly selective antagonists to μ-, δ-, and κ-opioid receptor subtypes on hyperosmotic- or angiotensin II (AII)-induced arginine vasotocin (AVT) release were investigated in chicks. Plasma levels of AVT increased about 1.5-fold after the administration of 1.5 M NaCl (200 μl, ip) or 100 ng AII (5 μl, icv). The administration of the μ-antagonist naloxonazine and the κ-antagonist nor-Binaltorphimine further elevated plasma levels of AVT stimulated by hypertonic NaCl or AII. These effects of μ- and κ-opioid receptor antagonists on AVT release were dose dependent. Nor-Binahorphimine enhanced hyperosmotically stimulated plasma levels of AVT at a lower dose than that of naloxonazine. Conversely, the δ-selective antagonist naltrindole did not significantly affect AVT secretion. None of the opioid receptor antagonists influenced basal plasma levels of AVT. Therefore, these results suggest that μ- and δ-opioid receptors are involved in hyperosmotic- and AII-induced AVT release, and the effect of the κ-opioid receptor antagonist in the AVT release stimulated by hyperosmolality is strong compared to that of the μ-opioid receptor antagonist, (C) 2000 Academic Press.
AB - The effects of highly selective antagonists to μ-, δ-, and κ-opioid receptor subtypes on hyperosmotic- or angiotensin II (AII)-induced arginine vasotocin (AVT) release were investigated in chicks. Plasma levels of AVT increased about 1.5-fold after the administration of 1.5 M NaCl (200 μl, ip) or 100 ng AII (5 μl, icv). The administration of the μ-antagonist naloxonazine and the κ-antagonist nor-Binaltorphimine further elevated plasma levels of AVT stimulated by hypertonic NaCl or AII. These effects of μ- and κ-opioid receptor antagonists on AVT release were dose dependent. Nor-Binahorphimine enhanced hyperosmotically stimulated plasma levels of AVT at a lower dose than that of naloxonazine. Conversely, the δ-selective antagonist naltrindole did not significantly affect AVT secretion. None of the opioid receptor antagonists influenced basal plasma levels of AVT. Therefore, these results suggest that μ- and δ-opioid receptors are involved in hyperosmotic- and AII-induced AVT release, and the effect of the κ-opioid receptor antagonist in the AVT release stimulated by hyperosmolality is strong compared to that of the μ-opioid receptor antagonist, (C) 2000 Academic Press.
KW - Angiotensin II
KW - Arginine vasotocin
KW - Chicks
KW - Hypertonic stimulation
KW - Naloxonazine
KW - Naltrindole
KW - Nor-BNI
KW - Opioid receptor
UR - http://www.scopus.com/inward/record.url?scp=0034044787&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034044787&partnerID=8YFLogxK
U2 - 10.1006/gcen.2000.7470
DO - 10.1006/gcen.2000.7470
M3 - Article
VL - 118
SP - 365
EP - 372
JO - General and Comparative Endocrinology
JF - General and Comparative Endocrinology
SN - 0016-6480
IS - 3
ER -