The effects of highly selective opioid receptor antagonists on the release of arginine vasotocin induced by hyperosmotic stimulation and angiotensin II injection

Takeshi Sasaki, Koji Arakawa, Kiyoshi Shimada, Noboru Saito

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The effects of highly selective antagonists to μ-, δ-, and κ-opioid receptor subtypes on hyperosmotic- or angiotensin II (AII)-induced arginine vasotocin (AVT) release were investigated in chicks. Plasma levels of AVT increased about 1.5-fold after the administration of 1.5 M NaCl (200 μl, ip) or 100 ng AII (5 μl, icv). The administration of the μ-antagonist naloxonazine and the κ-antagonist nor-Binaltorphimine further elevated plasma levels of AVT stimulated by hypertonic NaCl or AII. These effects of μ- and κ-opioid receptor antagonists on AVT release were dose dependent. Nor-Binahorphimine enhanced hyperosmotically stimulated plasma levels of AVT at a lower dose than that of naloxonazine. Conversely, the δ-selective antagonist naltrindole did not significantly affect AVT secretion. None of the opioid receptor antagonists influenced basal plasma levels of AVT. Therefore, these results suggest that μ- and δ-opioid receptors are involved in hyperosmotic- and AII-induced AVT release, and the effect of the κ-opioid receptor antagonist in the AVT release stimulated by hyperosmolality is strong compared to that of the μ-opioid receptor antagonist, (C) 2000 Academic Press.

Original languageEnglish
Pages (from-to)365-372
Number of pages8
JournalGeneral and Comparative Endocrinology
Volume118
Issue number3
DOIs
Publication statusPublished - Jun 2000
Externally publishedYes

Keywords

  • Angiotensin II
  • Arginine vasotocin
  • Chicks
  • Hypertonic stimulation
  • Naloxonazine
  • Naltrindole
  • Nor-BNI
  • Opioid receptor

ASJC Scopus subject areas

  • Animal Science and Zoology
  • Endocrinology

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