Abstract
Apomorphine, a selective dopamine receptor agonist is known to induce stereotyped behavior in rats. We studied the effect of Flunarizine (FZ) and Cinnarizine (C2) on apomorphine induced stereotyped behavior in rats. Fz at a dose of 25, 50, or 100 μmol/kg or CZ at a dose of 100, 500, or 2000 μmol/kg were given orally to rats, followed by administration of apomorphine at a dose of 2 mg/kg intraperitoneally, after an interval of 2 hours. Subsequently, the stereotyped behavior of the rats was observed over a period of 60 minutes. FZ caused a marked decrease in the intensity of the stereotypy induced by apomorpine in a dose-dependent manner. CZ also had a suppressive effect on the stereotypy but to a lesser degree than FZ. These results indicate that FZ is more potent than CZ as a CNS dopamine receptor blocker.
| Original language | English |
|---|---|
| Pages (from-to) | 703-708 |
| Number of pages | 6 |
| Journal | Japanese Journal of Neuropsychopharmacology |
| Volume | 14 |
| Issue number | 11 |
| Publication status | Published - 1992 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Pharmacology (medical)
- Neuroscience(all)
- Pharmacology, Toxicology and Pharmaceutics(all)
Cite this
The effects of flunarizine and cinnarizine on apomorphine induced stereotyped behavior in rats. / Kariya, S.; Isozaki, S.; Narimatsu, S.; Suzuki, T.
In: Japanese Journal of Neuropsychopharmacology, Vol. 14, No. 11, 1992, p. 703-708.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The effects of flunarizine and cinnarizine on apomorphine induced stereotyped behavior in rats
AU - Kariya, S.
AU - Isozaki, S.
AU - Narimatsu, S.
AU - Suzuki, T.
PY - 1992
Y1 - 1992
N2 - Apomorphine, a selective dopamine receptor agonist is known to induce stereotyped behavior in rats. We studied the effect of Flunarizine (FZ) and Cinnarizine (C2) on apomorphine induced stereotyped behavior in rats. Fz at a dose of 25, 50, or 100 μmol/kg or CZ at a dose of 100, 500, or 2000 μmol/kg were given orally to rats, followed by administration of apomorphine at a dose of 2 mg/kg intraperitoneally, after an interval of 2 hours. Subsequently, the stereotyped behavior of the rats was observed over a period of 60 minutes. FZ caused a marked decrease in the intensity of the stereotypy induced by apomorpine in a dose-dependent manner. CZ also had a suppressive effect on the stereotypy but to a lesser degree than FZ. These results indicate that FZ is more potent than CZ as a CNS dopamine receptor blocker.
AB - Apomorphine, a selective dopamine receptor agonist is known to induce stereotyped behavior in rats. We studied the effect of Flunarizine (FZ) and Cinnarizine (C2) on apomorphine induced stereotyped behavior in rats. Fz at a dose of 25, 50, or 100 μmol/kg or CZ at a dose of 100, 500, or 2000 μmol/kg were given orally to rats, followed by administration of apomorphine at a dose of 2 mg/kg intraperitoneally, after an interval of 2 hours. Subsequently, the stereotyped behavior of the rats was observed over a period of 60 minutes. FZ caused a marked decrease in the intensity of the stereotypy induced by apomorpine in a dose-dependent manner. CZ also had a suppressive effect on the stereotypy but to a lesser degree than FZ. These results indicate that FZ is more potent than CZ as a CNS dopamine receptor blocker.
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UR - http://www.scopus.com/inward/citedby.url?scp=0026620966&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:0026620966
VL - 14
SP - 703
EP - 708
JO - Yakubutsu, seishin, kodo = Japanese journal of psychopharmacology
JF - Yakubutsu, seishin, kodo = Japanese journal of psychopharmacology
SN - 1340-2544
IS - 11
ER -